{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:20:25Z","timestamp":1747149625257,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Down syndrome is the most common genetic disorder, and the life expectancy of patients with Down syndrome has increased over the decades. However, the diseases and social problems experienced by patients with Down syndrome remain unknown in Japan. Therefore, we aimed to investigate the disease status of such patients admitted to acute care hospitals in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational study was conducted using the Diagnosis Procedure Combination data from 2016 to 2021 to evaluate routes of admission, principal diagnoses, comorbidity of dementia, orthopedic surgeries for limb fractures, and discharge destinations of patients with Down syndrome (International Classification of Diseases, Tenth Revision code: Q90).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 26,195 individuals with Down syndrome were included, of whom 5195 were \u226520\u2009years of age. As the age increased, the number of admissions from home decreased and that from nursing homes increased. Pneumonia was the most common principal diagnosis, with the incidence of aspiration pneumonia increasing in patients &gt;40\u2009years of age. We observed an increase in the incidence of dementia and surgery for limb fractures after 40\u2009years of age. The number of discharges to home decreased with increasing age, whereas that to nursing homes increased with increasing age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that patients with Down syndrome are often hospitalized because of pneumonia and that the incidence of aspiration pneumonia, dementia, and limb fractures increases after 40\u2009years of age. Therefore, a system to prevent pneumonia, especially aspiration pneumonia, and limb fractures in patients with Down syndrome is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgf2.746","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T01:38:22Z","timestamp":1730252302000},"page":"135-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hospitalization of patients with Down syndrome in acute care hospitals in Japan"],"prefix":"10.1002","volume":"26","author":[{"given":"Keisuke","family":"Yasunami","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine and Community Health, School of Medicine University of Occupational and Environmental Health  Kitakyushu Japan"},{"name":"Department of Anesthesiology, School of Medicine University of Occupational and Environmental Health  Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-1939","authenticated-orcid":false,"given":"Ryutaro","family":"Matsugaki","sequence":"additional","affiliation":[{"name":"Department of Work Systems and Health, Institute of Industry Ecological Sciences University of Occupational and Environmental Health  Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Community Health, School of Medicine University of Occupational and Environmental Health  Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Community Health, School of Medicine University of Occupational and Environmental Health  Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61298"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33295"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1706537"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115215"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10204687"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.14354"},{"key":"e_1_2_10_8_1","first-page":"26","article-title":"Comparison of health status between at\u2010home\u2010care and institutionalized adults with Down syndrome in Japan","volume":"4","author":"Ueda K","year":"2020","journal-title":"Arch Intern Med"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.JNMS.2023_90-211"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20200288"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.37737\/ace.1.3_76"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.05.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61924"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-0225"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-014-9538-5"},{"key":"e_1_2_10_17_1","first-page":"1","article-title":"Signs of aspiration in adults with Down syndrome: prevalence as determined using a water swallowing screen and caregiver report","volume":"2","author":"Jasien J","year":"2016","journal-title":"J Neurol Neurobiol"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12196"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1352\/1934-9556-50.2.92"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17024"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-017-9341-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2006.00902.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00245-3"},{"key":"e_1_2_10_24_1","first-page":"51","article-title":"Characteristics of adults with down syndrome: prevalence of age\u2010related conditions","volume":"1","author":"Carf\u00ec A","year":"2014","journal-title":"Front Med (Lausanne)"},{"issue":"12","key":"e_1_2_10_25_1","first-page":"945","article-title":"Hip fracture: diagnosis, treatment, and secondary prevention","volume":"89","author":"LeBlanc KE","year":"2014","journal-title":"Am Fam Physician"},{"issue":"1","key":"e_1_2_10_26_1","article-title":"Bilateral femoral neck fractures resulting from a grand mal seizure in an elderly man with Down syndrome","volume":"2","author":"Marsh JP","year":"2010","journal-title":"Orthop Rev (Pavia)"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2490\/prm.20230033"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.je.2016.09.009"}],"container-title":["Journal of General and Family Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgf2.746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:02:08Z","timestamp":1741741328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgf2.746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,29]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/jgf2.746"],"URL":"https:\/\/doi.org\/10.1002\/jgf2.746","archive":["Portico"],"relation":{},"ISSN":["2189-7948","2189-7948"],"issn-type":[{"type":"print","value":"2189-7948"},{"type":"electronic","value":"2189-7948"}],"subject":[],"published":{"date-parts":[[2024,10,29]]},"assertion":[{"value":"2024-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}