{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T04:02:48Z","timestamp":1745640168452,"version":"3.40.4"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent advances in the management of transthyretin amyloid cardiomyopathy (ATTR\u2010CM) have highlighted the need for early identification. Studies have demonstrated amyloid deposits in orthopedic surgical specimens, prompting a diagnosis of concurrent ATTR\u2010CM. We sought to determine the prevalence of spinal amyloid deposits among patients undergoing spinal stenosis decompression surgery and whether the presence of deposits was associated with ATTR\u2010CM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients &gt;60\u2009years of age undergoing spinal stenosis decompression surgery were enrolled as part of a prospective, single\u2010center, cohort study. Samples from the disc and ligamentum flavum were obtained during surgery. Patients with amyloid deposition on Congo red staining returned for standard\u2010of\u2010care clinical assessment consisting of blood testing, a transthoracic echocardiogram, nuclear pyrophosphate imaging when indicated, and an evaluation with a cardiologist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 54 enrolled patients, 24 patients (44%; 95% CI, 31%\u201359%) were found to have spinal amyloid deposits. Amyloid\u2010positive patients were older than amyloid\u2010negative patients (70\u2009years vs. 63\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). On follow\u2010up testing, no amyloid\u2010positive patients were found to have definitive ATTR\u2010CM. However, 37% of amyloid\u2010positive patients had abnormal cardiac biomarkers, and 36% of amyloid\u2010positive patients had reduced global longitudinal strain on echocardiography, suggesting possible early disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Spinal amyloid deposits, in both the disc and ligamentum flavum, were found in 44% of older patients undergoing spinal stenosis decompression surgery. While none of these patients tested positive for ATTR\u2010CM on early follow\u2010up, subtle abnormalities in cardiac testing suggest that further follow\u2010up testing is warranted to detect the advent of cardiac amyloidosis in the future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgf2.766","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T05:40:56Z","timestamp":1737006056000},"page":"222-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spinal amyloid deposits are common among older patients undergoing spinal stenosis decompression surgery"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5747-6948","authenticated-orcid":false,"given":"Avni","family":"Madhani","sequence":"first","affiliation":[{"name":"Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navya","family":"Kotturu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Cardiovascular Medicine Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Fine","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Cardiovascular Medicine Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabah","family":"Alreshq","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Cardiovascular Medicine Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz","family":"Saade","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Tannoury","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chadi","family":"Tannoury","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick L.","family":"Ruberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Cardiovascular Medicine Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center  Boston Massachusetts USA"},{"name":"Amyloidosis Center Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv338"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805689"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716793"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716153"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021612"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.03.004"},{"key":"e_1_2_10_9_1","first-page":"147","article-title":"Lumbar spinal stenosis and spondylosis associated with amyloid deposition in the ligamentum flavum","volume":"11","author":"D'Agostino AN","year":"1992","journal-title":"Clin Neuropathol"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.11.017"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2017.1375908"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022876\u20109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.06.026"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.092"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.102"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2023.05.012"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2014.895786"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1759"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13222"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2021.1950681"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17976"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000003155"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000792"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/HCI.0000000000000029"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.054"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2021.1976450"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018852"}],"container-title":["Journal of General and Family Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgf2.766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:20:28Z","timestamp":1745565628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgf2.766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,15]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/jgf2.766"],"URL":"https:\/\/doi.org\/10.1002\/jgf2.766","archive":["Portico"],"relation":{},"ISSN":["2189-7948","2189-7948"],"issn-type":[{"type":"print","value":"2189-7948"},{"type":"electronic","value":"2189-7948"}],"subject":[],"published":{"date-parts":[[2025,1,15]]},"assertion":[{"value":"2024-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}