{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:49:08Z","timestamp":1789206548605,"version":"build-2803163510"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Gen and Family Med"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mesna (2\u2010mercaptoethane sulfonate Na), a drug that alleviates cyclophosphamide (<jats:styled-content style=\"fixed-case\">CYC<\/jats:styled-content>)\u2010induced hemorrhagic cystitis, is frequently used to treat cancer and collagen diseases. A 33\u2010year\u2010old woman presented with high fever during <jats:styled-content style=\"fixed-case\">CYC<\/jats:styled-content>\u2010based induction therapy for systemic lupus erythematosus. Her final diagnosis was mesna\u2010induced drug hypersensitivity. Although mesna is widely used, allergic reactions are rare. This may be because of misdiagnosis as a primary disease flare\u2010up, infection, or <jats:styled-content style=\"fixed-case\">CYC<\/jats:styled-content>\u2010induced hypersensitivity reaction, which are commonly reported. Thus, accurate diagnosis is important for completion of the <jats:styled-content style=\"fixed-case\">CYC<\/jats:styled-content>\u2010based regimen.<\/jats:p>","DOI":"10.1002\/jgf2.79","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T06:56:37Z","timestamp":1498114597000},"page":"285-287","source":"Crossref","is-referenced-by-count":6,"title":["Nonimmediate allergic reactions induced by Mesna"],"prefix":"10.1002","volume":"18","author":[{"given":"Kei","family":"Shimogori","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Suwa Central Hospital  Chino Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Suwa Central Hospital  Chino Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Shibazaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Suwa Central Hospital  Chino Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katuji","family":"Tuda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Suwa Central Hospital  Chino Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Suwa Central Hospital  Chino Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209133"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10461"},{"key":"e_1_2_7_4_1","first-page":"171","article-title":"Severe systemic hypersensitivity reaction to ibuprofen: a presentation of systemic lupus erythematosus","volume":"33","author":"Mou SS","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31817a241a"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70279-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.04.041"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12081"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370717"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31820c3403"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(85)90780-8"}],"container-title":["Journal of General and Family Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjgf2.79","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgf2.79","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:03:36Z","timestamp":1695485016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgf2.79"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,22]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/jgf2.79"],"URL":"https:\/\/doi.org\/10.1002\/jgf2.79","archive":["Portico"],"relation":{},"ISSN":["2189-7948","2189-7948"],"issn-type":[{"value":"2189-7948","type":"print"},{"value":"2189-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,22]]}}}