{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:11:35Z","timestamp":1768446695946,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Science & Technology Development Foundation (STDF)","award":["1784 (TC\/2\/Health\/2009\/hep-1.3)"],"award-info":[{"award-number":["1784 (TC\/2\/Health\/2009\/hep-1.3)"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Polymorphisms in some genes may influence the persistence of hepatitis C virus (HCV) infection, clinical outcome, HCV replication, and liver damage. This study was conducted to investigate the role of the interferon gamma (IFN\u2010\u03b3) gene at (+874 T\/A, \u2212764 G\/C, \u2212179 C\/A) single\u2010nucleotide polymorphisms (SNPs) and its receptor (IFN\u2010\u03b3R2) at (rs 2786067 A\/C) SNP in the susceptibility of Egyptian families to HCV infection with high\u2010resolution techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 517 Egyptian families, with 2246 subjects, were recruited to this study from the Upper and Lower Egypt governorates and were classified into three groups: 1034 patients with chronic hepatitis C virus, 108 subjects with spontaneous virus clearance (SVC), and 1104 subjects as a healthy control group. All subjects were genotyped for (+874 T\/A, rs2430561, \u2212764 G\/C, rs2069707, \u2212179 C\/A, rs2069709, and rs 27860067, A\/C) SNPs of the IFN\u2010\u03b3 gene using the allelic discrimination real\u2010time polymerase chain reaction technique and were confirmed using sequence\u2010based typing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The carriage of T allele of (+874) IFN\u2010\u03b3 is a risky allele and was significantly higher in chronic hepatitis C more than other two groups (odds ratio [OR]: 2.6646, <jats:italic>P<\/jats:italic> &lt; 0.0002). On the other hand, the C allele of (\u2212764, rs2069707) is a protective allele and was higher in SVC than the other two groups (OR: 0.2709, <jats:italic>P<\/jats:italic> &lt; 0.0001). However, both (\u2212179 C\/A, rs 2069709) and (rs 27860067, A\/C) SNPs are not polymorphic enough to be studied in the Egyptian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HCV infection is associated with the T allele of (+874 rs2430561), while SVC of HCV is associated with the C allele of (\u2212764, rs2069707) of the IFN\u2010\u03b3 gene.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12024","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T08:31:16Z","timestamp":1514017876000},"page":"140-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of interferon gamma gene polymorphism and susceptibility to hepatitis C virus infection in Egyptian patients: A multicenter, family\u2010based study"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-5927","authenticated-orcid":false,"given":"Mahmoud","family":"El\u2010Bendary","sequence":"first","affiliation":[{"name":"Tropical Medicine and Hepatology Department, Mansoura Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Neamatallah","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department, Mansoura Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatem","family":"Elalfy","sequence":"additional","affiliation":[{"name":"Tropical Medicine and Hepatology Department, Mansoura Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Besheer","sequence":"additional","affiliation":[{"name":"Tropical Medicine and Hepatology Department, Mansoura Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maged","family":"El\u2010Setouhy","sequence":"additional","affiliation":[{"name":"Department of Community, Environmental and Occupational Medicine, Ain\u2010Shams Faculty of Medicine Ain\u2010Shams University  Cairo Egypt"},{"name":"Substance Abuse Research Center (SARC) Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal","family":"Kasim","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Science Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha T","family":"Abou El\u2010Khier","sequence":"additional","affiliation":[{"name":"Medical Microbiology and Immunology Department, Faculty of Medicine Mansoura University  Mansoura 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