{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:44:41Z","timestamp":1785843881090,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Nodular gastritis is caused by <jats:italic>Helicobacter pylori<\/jats:italic> infection and is associated with the development of diffuse\u2010type gastric cancer. This study examined the clinical characteristics of patients with nodular gastritis, including cancer incidence before and after <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of patients who underwent upper endoscopy and were positive for <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infection. We examined the clinical findings and follow\u2010up data after <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradication in patients with and without nodular gastritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 674 patients with <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infections, nodular gastritis was observed in 114 (17%). It was more prevalent in women (69%) and young adults. Among patients with nodular gastritis, six (5%) had gastric cancer, all of which were of the diffuse type. Among the 19 (4%) patients with gastric cancer and no nodular gastritis, 16 had intestinal\u2010type cancer. White spot aggregates in the corpus, a specific finding in patients with nodular gastritis, were more frequently observed in patients with gastric cancer than in those without (83% <jats:italic>vs<\/jats:italic> 26%, <jats:italic>P<\/jats:italic>\u2009=\u20090.0025). Of 82 patients with nodular gastritis who had <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradicated successfully, none developed gastric cancer over a 3\u2010year follow\u2010up period, while 7 (3%) of 220 patients without nodular gastritis developed gastric cancer after <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with nodular gastritis, white spot aggregates in the corpus may indicate a higher risk of developing diffuse\u2010type gastric cancer. Nodular gastritis may be an indication for eradication therapy to reduce the risk of cancer development after <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradication.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12049","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T03:12:19Z","timestamp":1522033939000},"page":"80-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Nodular gastritis in association with gastric cancer development before and after <i>Helicobacter pylori<\/i> eradication"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-8930","authenticated-orcid":false,"given":"Izumi","family":"Nishikawa","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine Hidaka General Hospital  Wakayama 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