{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:09:22Z","timestamp":1740179362182,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"BioMedical Development and Innovation & Incubation Center, MacKay Memorial Hospital","award":["BMD-105-008"],"award-info":[{"award-number":["BMD-105-008"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background and aim<\/jats:title><jats:p>To assess the detection rates of <jats:italic>Helicobacter pylori<\/jats:italic> colonization in the gastric cardia with two commercial kits of rapid urease test: 5 min UFT300 and 24\u2009h CLO test in <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content>\u2010infected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty consecutive dyspeptic patients with confirmed <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infection (serology and <jats:sup>13<\/jats:sup>C\u2010urea breath test) were prospectively studied. During endoscopy, tissue samples using separate biopsy forceps from the cardia were taken for the UFT300 and CLO tests. The results of the UFT300 were read at 5 and 30\u2009min, and those of the CLO test were read at 24\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 80 enrolled patients, 17 (21.3%) and 44 (55%) had positive findings with the UFT300 at 5 and 30\u2009min, respectively, while 72 (90%) had positive findings with the CLO test at 24\u2009h. The CLO test is significantly more sensitive than the UFT300 in evaluating <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> status in the cardia. On comparing patients with and without carditis, the detection rates of the CLO test were similar (91.1% <jats:italic>vs<\/jats:italic> 88.6%; <jats:italic>P<\/jats:italic> = 0.724), and the rates of the UFT300 were also similar at 5 and 30\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The rate of <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> colonization in the gastric cardia was 90% in <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content>\u2010infected patients detected with the CLO test. Although the UFT300 provides a more rapid reading of <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> status, the diagnostic yield of the CLO test is much higher than that of the UFT300. However, a positive result of the UFT300 may indicate a higher bacterial load in the cardia, which warrants a more effective therapeutic strategy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12053","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T07:39:52Z","timestamp":1526369992000},"page":"93-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Colonization of <i>Helicobacter pylori<\/i> in the gastric cardia: A comparison between the UFT300 and CLO tests"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1935-4688","authenticated-orcid":false,"given":"Po\u2010Hao","family":"Liao","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Mackay Memorial Hospital  New Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Chun","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Mackay Memorial Hospital  New Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Hsin","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shou\u2010Chuan","family":"Shih","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai\u2010Cherng","family":"Liou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.11.016"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1868"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-182"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90011-6"},{"key":"e_1_2_6_6_1","first-page":"2220","article-title":"Prevalence and pattern of Helicobacter pylori gastritis in the gastric cardia","volume":"92","author":"Hackelsberger A","year":"1997","journal-title":"Am. 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