{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:12:39Z","timestamp":1790885559649,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Liver diseases are a major public health problem, accounting for a significant number of hospital visits and admissions and an increasing mortality rate. Melatonin (MLT) is a powerful antioxidant molecule that has been shown to be beneficial under various conditions. The objective was to evaluate the effect of MLT on experimental liver cirrhosis induced by carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty male Wistar rats (230\u2013250 g) were divided into four groups. I: control group (CO); II: CO + MLT; III: CCl<jats:sub>4<\/jats:sub>; and IV: CCl<jats:sub>4<\/jats:sub> + MLT. CCl<jats:sub>4<\/jats:sub> was administered intraperitoneally (i.p.) as follows: 10 doses every 5 days, 10 doses every 4 days, and 7 doses every 3 days. MLT was administered i.p. at a dose of 20 mg\/kg from the 10th week to the end of the experiment (16th week).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the CCl<jats:sub>4<\/jats:sub> + MLT group, we found that MLT caused a decrease in the level of F2\u2010isoprostanes and NQO1 expression. We also found that MLT reduced the inflammatory process as shown by decreased expressions of NF\u2010KB\/p65 and inducible nitric oxide synthase (iNOS) and a smaller amount of inflammatory infiltrate. MLT reduced the expression of transforming growth factor beta1 (TGF\u2010\u03b21), alpha\u2010smooth muscle actin (\u03b1\u2010SMA), and vascular endothelial growth factor (VEGF). Picrosirius staining showed that MLT decreases fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MLT has a potent antifibrogenic effect, modulating the parameters of oxidative stress, angiogenesis, and inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12055","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T06:30:36Z","timestamp":1527229836000},"page":"117-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antifibrogenic effect of melatonin in rats with experimental liver cirrhosis induced by carbon tetrachloride"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-440X","authenticated-orcid":false,"given":"Silvia","family":"Bona","sequence":"first","affiliation":[{"name":"Center of Experimental Research Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre RS Brazil"},{"name":"Postgraduate 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