{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T08:52:30Z","timestamp":1779007950867,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T00:00:00Z","timestamp":1533168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background\/Aim<\/jats:title><jats:p>Many studies have investigated risk factors other than antibiotic resistance linked to <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) eradication failure. The aim of this study was to study the effect of serum levels of 25\u2010hydroxy\u2010vitamin D (25[OH]D) on eradication rates of <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 150 patients diagnosed with <jats:italic>H. pylori<\/jats:italic> gastritis using magnifying narrow\u2010band imaging endoscopy supported by stool antigen test. Serum 25\u2010OH vitamin D levels were measured via the Enzyme\u2010Linked Immune Sorbent assay (ELISA) method before starting eradication therapy of <jats:italic>H. pylori<\/jats:italic> infection. All patients were treated with clarithromycin\u2010based triple therapy for 14\u2009days. <jats:italic>H. pylori<\/jats:italic> eradication was determined via a stool antigen test performed 4\u2009weeks after the end of therapy. According to the serum level of 25\u2010OH vitamin D levels, the patients were divided into two groups: group I (sufficient) had a vitamin D level of \u226520\u2009ng\/mL, while group II (deficient) had a vitamin D level of &lt;20\u2009ng\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results revealed that eradication was successful in 105 (70%) patients and failed in 45 (30%) patients. The mean 25[OH]D level was significantly lower in the eradication failure group compared to the successful treatment group (14.7\u2009\u00b1\u20094.5 <jats:italic>vs<\/jats:italic> 27.41\u2009\u00b1\u20097.1; <jats:italic>P<\/jats:italic> &lt; 0.001). Furthermore, there were significantly more patients with deficient 25[OH]D levels in the failed treatment group, 30 (66.6%), compared to the successful group, 10 (9.5%) (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrated that 25\u2010OH vitamin D deficiency may be considered a risk factor related to eradication failure of <jats:italic>H. pylori<\/jats:italic> infection. In addition, a further randomized trial to evaluate the effect of vitamin D supplementation in <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradication is mandatory.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12081","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T03:53:57Z","timestamp":1533614037000},"page":"270-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The effect of vitamin D deficiency on eradication rates of <i>Helicobacter pylori<\/i> infection"],"prefix":"10.1002","volume":"2","author":[{"given":"Mohamed S","family":"El Shahawy","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology Unit, Faculty of Medicine AL\u2010Azhar University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud H","family":"Hemida","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Immunology Unit, Faculty of Medicine AL\u2010Azhar University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"El Metwaly","sequence":"additional","affiliation":[{"name":"Department of Clinical pathology, Faculty of Medicine AL\u2010Azhar University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zakarya M","family":"Shady","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology Unit, Faculty of Medicine AL\u2010Azhar University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.5302"},{"issue":"1","key":"e_1_2_6_3_1","first-page":"45","article-title":"Helicobacter pylori infection: A recent approach to diagnosis and management","volume":"2","author":"Ramesh R","year":"2017","journal-title":"J. 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