{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:11:41Z","timestamp":1785449501875,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The diagnosis of Hirschsprung's disease (HD) relies on anorectal manometry and rectal biopsy. The role of endoscopic biopsy is uncertain for the diagnosis of HD in children. In this study, we evaluated the adequacy of biopsies procured by endoscopic mucosal resection (EMR) for the diagnosis of HD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive children with suspected HD from January 2013 to January 2018 were enrolled in the study. EMR was performed using the standard band ligation device at a distance of about 3 cm from dentate line in rectum. All samples were assessed macroscopically and microscopically. An adequate sample was defined as those measuring &gt;3 mm and including adequate submucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 132 children underwent evaluation for constipation in the study period. Of these, 10 children (median age, 4.25\u2009years) underwent EMR using the band ligation device for the evaluation of HD. EMR was performed with and without submucosal lifting injection in four and six children, respectively. All the samples were adequate macroscopically (&gt;3 mm). Absence of ganglion cells was noted in six children. Of these, three children underwent full\u2010thickness rectal biopsy followed by surgery. Three children did not undergo surgery. Ganglion cells were identified in four children, thereby excluding the diagnosis of HD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rectal biopsy using EMR with a band ligation device is feasible, safe, and provides adequate sample for the evaluation of HD in children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12092","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T20:08:28Z","timestamp":1538770108000},"page":"322-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnosis of Hirschsprung's disease in children: Preliminary evaluation of a novel endoscopic technique for rectal biopsy"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-4781","authenticated-orcid":false,"given":"Zaheer","family":"Nabi","sequence":"first","affiliation":[{"name":"Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upender","family":"Shava","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Sekharan","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duvvur","family":"Nageshwar Reddy","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311872"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.01.044"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000252188.12793.ee"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.08.037"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.vgie.2018.02.008","article-title":"A novel endoscopic technique to obtain rectal biopsy specimens in children with suspected Hirschsprung's disease","volume":"3","author":"Nabi Z","year":"2018","journal-title":"Video GIE"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000679"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198910000-00013"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198508000-00018"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-008-2293-7"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1072221"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2009.07.003"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.465"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.cgh.2015.04.186","article-title":"Infant's age influences the accuracy of rectal suction biopsies for diagnosing of Hirschsprung's disease","volume":"13","author":"Meinds RJ","year":"2015","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00383-016-3907-0","article-title":"Current practice patterns of rectal suction biopsy in the diagnostic work\u2010up of Hirschsprung's disease: results from an international survey","volume":"32","author":"Friedmacher F","year":"2016","journal-title":"Pediatr. Surg. Int."},{"key":"e_1_2_5_16_1","first-page":"100","article-title":"Effectiveness of rectal suction biopsy in diagnosing Hirschsprung disease","volume":"26","author":"Keyzer\u2010Dekker CM","year":"2016","journal-title":"Eur. J. Pediatr. Surg."},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00383-002-0876-2","article-title":"Rectal biopsy: what is the optimal procedure?","volume":"18","author":"Kobayashi H","year":"2002","journal-title":"Pediatr. Surg. Int."},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003830050264"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjgh3.12092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T23:51:09Z","timestamp":1694821869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,4]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/jgh3.12092"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12092","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,4]]},"assertion":[{"value":"2018-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}