{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T08:46:47Z","timestamp":1766738807666,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Clinical significance of ileocecal thickening on computed tomography (CT) is uncertain. We conducted this prospective study to determine the clinical relevance of ileal and\/or cecal thickening on CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with ileocecal thickening on CT were prospectively evaluated with ileocolonoscopy, biopsy, and other relevant investigations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty patients (29 males, mean age 36.8 \u00b1\u200913.21\u2009years) were studied. Thirty nine (78%) patients presented with abdominal pain. On CT, 46 (92%) had a thickened wall of terminal ileum, 25 (50%) cecum, and 21 (42%) of both cecum and ileum. The mean wall thickness of ileum and cecum on CT was 7.23\u2009+ 3.2 mm and 5.5 + 3.1 mm, respectively. Final diagnosis was tuberculosis in 24 (48%) patients, Crohn's disease (CD) in 10 (20%), and adenocarcinoma in 1 patient. Colonoscopy demonstrated abnormal findings in 41 patients (82% patients with mucosal ulcerations being most common (<jats:italic>n<\/jats:italic> =\u200920 (40%). Of 15 (30%) patients with ileocecal bowel wall thickening, 4 (8%) patients had normal colonoscopy and histopathology (incidental ileocecal wall thickening), and in the remaining 11 patients, histopathology showed non\u2010specific findings and these patients were asymptomatic without any specific treatment on last follow up ranging from 3 to 24\u2009months. Involvement of cecum with ileocecal junction, ascending colon involvement, peri\u2010ileocecal stranding, and long\u2010segment stricture was significantly more common in patients with underlying disease as compared to nondiseased patients (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A majority of patients with ileocecal wall thickening on CT have an underlying disease and should be further investigated by ileocolonoscopy and biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12103","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T01:50:52Z","timestamp":1540259452000},"page":"46-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Significance of ileal and\/or cecal wall thickening on abdominal computed tomography in a tropical country"],"prefix":"10.1002","volume":"3","author":[{"given":"Amit","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5245-9380","authenticated-orcid":false,"given":"Surinder S","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritambhra","family":"Nada","sequence":"additional","affiliation":[{"name":"Department of Histopathology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen","family":"Kalra","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi K","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usha","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Surgery Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.176.5.1761105"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.0712"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.148.5.863"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1148\/radiology.215.1.r00ap30103","article-title":"Gastrointestinal wall thickening inpatients with cirrhosis: frequency and patterns at contrast\u2010enhanced CT","volume":"215","author":"Karahan OI","year":"2000","journal-title":"Radiology"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.11.5.1947313"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1155\/2012\/282603","article-title":"Etiology of small bowel thickening on computed tomography","volume":"26","author":"Finkelstone L","year":"2012","journal-title":"Can. 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