{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:58:01Z","timestamp":1779890281331,"version":"3.53.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Children with intestinal failure (IF) have abnormal intestinal anatomy, secretion, or motility, which impairs homeostatic mechanisms and can lead to small intestinal bacterial overgrowth (SIBO). We sought to describe clinical features at the time of clinically suspected SIBO by experienced clinicians in children with IF on home parenteral nutrition (PN), review specific challenges of diagnostic testing in this population, and describe potential new diagnostic surrogate markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A descriptive single\u2010center retrospective chart review was performed during all episodes of clinically suspected SIBO over 33\u2009months. Information was recorded on clinical symptoms, and diagnostic tests performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of all patients on home PN, 71% (12\/17) had at least one episode of clinically suspected SIBO (mean 1 episode\/year, range 1\u20137); 50% of patients had short bowel syndrome (SBS), and 50% had non\u2010SBS IF. The average reported symptoms per episode were 1.9 (range 1\u20135). Children with SBS reported fewer symptoms per episode (1.5) than children with non\u2010SBS IF (2.3). Diarrhea was the most commonly reported symptom, particularly in children with SBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children with IF on home PN are a high\u2010risk group for SIBO. Clinical features of SIBO vary depending on the cause of IF and may mimic symptoms of the underlying condition. Diagnostic tests have innate challenges in this group, and a strong index of clinical suspicion is paramount. Further research is recommended into potential new surrogate markers (urinary metabolite screen, gastric aspirate) for this diagnostically challenging population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12174","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T07:35:41Z","timestamp":1554363341000},"page":"394-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Small intestinal bacterial overgrowth in children with intestinal failure on home parenteral nutrition"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0016-6441","authenticated-orcid":false,"given":"Kathleen H","family":"McGrath","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition The Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Intestinal Failure and Clinical Nutrition Group Murdoch Children's Research Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Pitt","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The University of Melbourne  Melbourne Victoria Australia"},{"name":"Victorian Clinical Genetics Services Murdoch Children's Research Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie E","family":"Bines","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition The Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Intestinal Failure and Clinical Nutrition Group Murdoch Children's Research Institute  Melbourne Victoria Australia"},{"name":"Department of Paediatrics The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2016.09.008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000920"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196404302701806"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0065-1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000103892"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12456"},{"issue":"1","key":"e_1_2_5_8_1","first-page":"1","article-title":"1st Rome H2\u2010Breath Testing Consensus Conference Working Group. 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