{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T14:03:11Z","timestamp":1773496991532,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["RTA5980008"],"award-info":[{"award-number":["RTA5980008"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Fibrotic stage (FS) assessment is essential in chronic hepatitis C treatment cascade. Liver stiffness measurement (LSM) using transient elastography (TE) is reliable and correlated with liver biopsy. However, TE may not be widely available. This study aimed to evaluate the diagnostic performances of aspartate aminotransferase to platelet ratio index (APRI) and fibrosis 4 (FIB\u20104) scores compared with TE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicenter, cross\u2010sectional study, including all chronic hepatitis C virus (HCV) monoinfection patients with successful and reliable LSM, at 10 centers in Thailand from 2012 to 2017. Characteristics and laboratory data within 3\u2009months of TE were retrospectively reviewed. Using TE as a reference standard, the diagnostic performances of APRI and FIB\u20104 were evaluated. TE cut\u2010off levels of 7.1 and 12.5\u2009kPa represented significant fibrosis (SF) and cirrhosis, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution of FS by TE in 2000 eligible patients was as follows: no SF 28.3%, SF 31.4%, and cirrhosis 40.3%. APRI\u2009\u2265\u20091 provided 70.1% sensitivity and 80.6% specificity, with an area under the receiver operator characteristics curve (AUROC) of 0.834 for cirrhosis. The specificity increased to 96.3% when using a cut\u2010off level of APRI\u2009\u2265\u20092. FIB\u20104\u2009\u2265\u20091.45 provided a sensitivity, specificity, and AUROC of 52.4%, 91.0%, and 0.829 for cirrhosis, respectively. For SF, APRI performed better than FIB\u20104, with an AUROC of 0.84 <jats:italic>versus<\/jats:italic> 0.80 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). APRI score\u2009&lt;\u20090.5 and FIB\u20104 score\u2009&gt;\u20091.45 yielded sensitivities of 82.3% and 74.4% and specificities of 65.4% and 69.8%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>APRI and FIB\u20104 scores had good diagnostic performances for FS assessment compared with TE, especially for cirrhosis. APRI may be used as the noninvasive assessment in resource\u2010limited settings for HCV patients\u2019 management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12219","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T11:39:33Z","timestamp":1561549173000},"page":"69-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of aspartate aminotransferase to platelet ratio index and fibrosis 4 scores for hepatic fibrosis assessment compared with transient elastography in chronic hepatitis C patients"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-8214","authenticated-orcid":false,"given":"Pimsiri","family":"Sripongpun","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine, Prince of Songkla University  Hat Yai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-8671","authenticated-orcid":false,"given":"Pisit","family":"Tangkijvanich","sequence":"additional","affiliation":[{"name":"Center of Excellence in Hepatitis and Liver Cancer Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Watcharasak","family":"Chotiyaputta","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8334-0267","authenticated-orcid":false,"given":"Phunchai","family":"Charatcharoenwitthaya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7191-3881","authenticated-orcid":false,"given":"Roongruedee","family":"Chaiteerakij","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6459-8329","authenticated-orcid":false,"given":"Sombat","family":"Treeprasertsuk","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8842-032X","authenticated-orcid":false,"given":"Chalermrat","family":"Bunchorntavakul","sequence":"additional","affiliation":[{"name":"Department of Medicine Rajavithi Hospital  Bangkok 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