{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T11:06:48Z","timestamp":1771931208414,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The United Kingdom\u2010primary biliary cholangitis (UK\u2010PBC) and global primary biliary cholangitis group (GLOBE) prognostic models have been recently developed to predict long\u2010term outcomes in primary biliary cholangitis (PBC). However, these predictive scores have not yet been well evaluated in the U.S. population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed newly diagnosed PBC patients at the Cleveland Clinic between November 1998 and February 2017. Adverse events were defined as liver transplantation, liver\u2010related mortality, and all\u2010cause mortality. Transplant\u2010free survival (TFS) was estimated using the Kaplan\u2013Meier method. Predictive performances of all prognostic models were evaluated using the C\u2010statistic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 352 patients who used ursodeoxycholic acid therapy. Of them, 311 (88.4%) only had PBC, while 41 (11.6%) were diagnosed with PBC\u2010autoimmune hepatitis overlap. A total of 22 (6%), 47 (13%), and 55 (16%) patients had adverse events within 5, 10, and 15\u2009years after diagnosis, respectively. In patients with PBC only, the C\u2010statistic in predicting 15\u2010year adverse events was 0.75 per GLOBE compared to 0.74 per UK\u2010PBC (<jats:italic>P<\/jats:italic> =\u20090.94), 0.73 per Rotterdam (<jats:italic>P<\/jats:italic> =\u20090.44), 0.66 per Barcelona (<jats:italic>P<\/jats:italic> =\u20090.004), 0.65 per Paris 1 (<jats:italic>P<\/jats:italic> =\u20090.005), 0.62 per Paris 2 (<jats:italic>P<\/jats:italic> &lt;\u20090.0001), 0.60 per Toronto (<jats:italic>P<\/jats:italic> &lt;\u20090.0001), and 0.60 per Mayo (<jats:italic>P<\/jats:italic> &lt;\u20090.0001) scores. Median follow\u2010up was 9.2\u2009years. Ten\u2010year TFS for patients who had optimal <jats:italic>versus<\/jats:italic> suboptimal treatment response was 92 <jats:italic>versus<\/jats:italic> 74% per Paris 1 (<jats:italic>P<\/jats:italic> &lt;\u20090.0001), 95 <jats:italic>versus<\/jats:italic> 79% per Paris 2 (<jats:italic>P<\/jats:italic> =\u20090.0002), 93 <jats:italic>versus<\/jats:italic> 65% per Barcelona (<jats:italic>P<\/jats:italic> &lt;\u20090.0001), and 96 <jats:italic>versus<\/jats:italic> 68% per Rotterdam (<jats:italic>P<\/jats:italic> &lt;\u20090.0001) risk scores, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our cohort of PBC patients, the UK\u2010PBC and GLOBE scores were both accurate and reasonably valid prognostic models in the U.S. population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12223","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T13:33:27Z","timestamp":1563802407000},"page":"132-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the United Kingdom\u2010primary biliary cholangitis and global primary biliary cholangitis group prognostic models for primary biliary cholangitis patients treated with ursodeoxycholic acid in the U.S. population"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1201-0866","authenticated-orcid":false,"given":"Mohammad","family":"Alomari","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahrettin","family":"Covut","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laith","family":"Al Momani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine East Tennessee State University  Johnson City Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravallika","family":"Chadalavada","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Hitawala","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark F","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology East Tennessee State University  Johnson City Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Romero\u2010Marrero","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Nutrition, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2015.08.001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20197"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(03)00102-8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043898"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2008.02.001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22906"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1677"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290301"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91610-2"},{"key":"e_1_2_5_11_1","first-page":"842","article-title":"Predicting outcomes of primary biliary cholangitis using the GLOBE score","volume":"11","author":"Mayo MJ","year":"2015","journal-title":"Gastroenterol. Hepatol. (N Y)"},{"key":"e_1_2_5_12_1","unstructured":"Research C for DE and Drug Approvals and Databases \u2010 Drug Trials Snapshots: OCALIVA. Cited 5 Feb 2019. Available from URL:https:\/\/www.fda.gov\/Drugs\/InformationOnDrugs\/ucm508093.htm"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.329"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90696-7"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90085-Y"},{"key":"e_1_2_5_16_1","first-page":"35","article-title":"Mayo risk score for primary biliary cirrhosis: a useful tool for the prediction of course after liver transplantation?","volume":"13","author":"Jacob DA","year":"2008","journal-title":"Ann. Transplant."},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.003"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22428"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.031"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.216"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.029"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12522"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28017"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.061"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-017-9819-9"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13294"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432479"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/801983"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.08.029"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.12.005"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000440754"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.20894"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.038"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20123"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2017.23"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1333-2"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.009"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198301063080101"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308351"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00699.x"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjgh3.12223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.12223","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T09:34:42Z","timestamp":1694079282000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,22]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/jgh3.12223"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12223","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,22]]},"assertion":[{"value":"2019-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}