{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:28:57Z","timestamp":1790616537025,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>To explore the risk factors of hyponatremia caused by terlipressin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four patients with acute variceal bleeding treated with terlipressin from December 2016 to December 2018 were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the treatment, serum sodium levels decreased from 137.78 to 126.59\u2009mmol\/L (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), with an average decrease of 11.19\u2009mmol\/L. The serum sodium level decreased by less than 5\u2009mmol\/L in 12 patients (27.27%), by 5\u201310\u2009mmol\/L in 13 patients (27.27%), and by more than 10\u2009mmol\/L in 19 patients (43.18%). The difference in baseline serum sodium levels was statistically significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and the differences in baseline total bilirubin levels, Child\u2010Pugh scores, and model for end\u2010stage liver disease scores were also significant. Logistic regression analysis suggested that the initial sodium level was an independent risk factor for the decrease in the serum sodium concentration caused by terlipressin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of hyponatremia is not low during treatment with terlipressin; a higher baseline serum sodium level is a risk factor for hyponatremia during treatment with terlipressin, and the mechanism may be related to endogenous vasopressin preconditioning.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12254","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T08:49:30Z","timestamp":1571647770000},"page":"368-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A retrospective analysis of hyponatremia during terlipressin treatment in patients with esophageal or gastric variceal bleeding due to portal hypertension"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3562-2822","authenticated-orcid":false,"given":"Xv","family":"Han","sequence":"first","affiliation":[{"name":"Tianjin Second People's Hospital Tianjin Hepatopathy Research Institute  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0100-417X","authenticated-orcid":false,"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Second People's Hospital Tianjin Hepatopathy Research Institute  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin Second People's Hospital Tianjin Hepatopathy Research Institute  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gao","sequence":"additional","affiliation":[{"name":"Tianjin Second People's Hospital Tianjin Hepatopathy Research Institute  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Second People's Hospital Tianjin Hepatopathy Research Institute  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309262"},{"key":"e_1_2_5_4_1","first-page":"203","article-title":"Guidelines for the prevention and treatment of patients with esophageal or gastric variceal bleeding due to Portal Hypertension","volume":"32","author":"Chinese Society of Hepatology, Chinese Society of gastroenterology, Chinese Society of endoscopy, etc","year":"2016","journal-title":"J. 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