{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:04:57Z","timestamp":1769522697871,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Papillary treatment, such as endoscopic sphincterotomy or endoscopic papillary balloon dilation, and subsequent single\u2010stage endoscopic stone removal are often performed for choledocholithiasis; however, the incidence of postendoscopic retrograde cholangiopancreatography pancreatitis (PEP) is unclear. This study aimed to compare the overall incidence of PEP between single\u2010 and two\u2010stage stone removal groups and the incidence of PEP between these two groups based on cannulation time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 897 patients with native papilla who underwent papillary treatment and stone removal for choledocholithiasis with no inflammation or mild\u2010to\u2010moderate acute cholangitis at three institutions between April 2012 and March 2018 in Japan. We performed a propensity\u2010matched analysis and regression adjustment by propensity score to adjust for potential confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the propensity\u2010matched analysis with 234 pairs, there was no significant difference in the overall incidence of PEP between single\u2010 and two\u2010stage stone removal procedures (15\/234, 6.4% <jats:italic>vs<\/jats:italic> 6\/234, 2.6%, <jats:italic>P<\/jats:italic> = 0.072, respectively). Although single\u2010stage stone removal after a cannulation time of \u226415\u2009min was not a significant risk factor of PEP, the procedure after a cannulation time of &gt;15\u2009min was a significant risk factor of PEP as estimated by regression adjustment by propensity score (<jats:italic>P<\/jats:italic> = 0.014, 95% CI = 1.4\u201319.4, odds ratio = 5.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Single\u2010stage endoscopic stone removal after a long cannulation time of &gt;15\u2009min increased the incidence of PEP compared with the two\u2010stage stone removal procedure. Thus, single\u2010stage stone removal should be performed in patients with a cannulation time\u2009\u2264\u200915\u2009min.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12263","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T08:36:34Z","timestamp":1571128594000},"page":"394-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Post\u2010endoscopic retrograde cholangiopancreatography pancreatitis in single\u2010stage endoscopic common bile duct stone removal"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8729-9604","authenticated-orcid":false,"given":"Hirokazu","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Kumamoto Chuo Hospital  Kumamoto City Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Kumamoto Hospital  Kumamoto City Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Kumamoto Hospital  Kumamoto City Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Kadono","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Kumamoto Hospital  Kumamoto City Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Kamikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Kumamoto Hospital  Kumamoto City Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Urata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Kumamoto Hospital  Kumamoto City Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Kumamoto Hospital  Kumamoto City Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kumamoto City Hospital  Kumamoto City Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyuki","family":"Kakuma","sequence":"additional","affiliation":[{"name":"Department of Biostatics Center, Medical School Kurume University  Kurume City Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kumamoto Chuo Hospital  Kumamoto City Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.04.012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1289-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312317"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13029"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.509"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.07.010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1377875"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9123-17"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.512"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.11.006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(91)70740-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj149"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14604"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.06.045"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1359-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.296"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.06.015"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1569573"},{"key":"e_1_2_6_20_1","first-page":"730","article-title":"Results of a multicenter trial using a mechanical lithotripter for the treatment of large bile duct stones","volume":"88","author":"Shaw MJ","year":"1993","journal-title":"Am. 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