{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:37:02Z","timestamp":1778701022576,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Routine use of water\u2010soluble contrast enema (WSCE) to assess anastomotic integrity is debated. This study aimed to evaluate the role of WSCE to assess anastomotic integrity following anterior resections (AR) with defunctioning stoma prior to reversal and identify factors to limit its selective use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study evaluated all WSCE performed over a 7\u2010year period at a high\u2010volume colorectal unit. Risk factors for radiological abnormality\/leak, including malignancy, chemoradiotherapy, and immediate postoperative complications, were recorded. A gastrointestinal specialist radiologist and surgeon validated all WSCEs reported as abnormal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 486 WSCE studies identified, 92 were excluded (repeat studies (<jats:italic>n<\/jats:italic> =\u200951), pediatric cases [<jats:italic>n<\/jats:italic> =\u20092], no AR [<jats:italic>n<\/jats:italic> =\u200939]). A total of 394 WSCE studies were evaluated (260 cancer; 134 noncancer patients); 14% (37\/260) of cancer patients and 8% (10\/134) of noncancer patients had abnormal studies (<jats:italic>P<\/jats:italic> =\u20090.072). Of the 37 abnormal studies in cancer patients, 73% (27\/37) radiological leaks were found, and 41% (<jats:italic>n<\/jats:italic> =\u200911\/27) of these patients had postoperative complications. Of the 10 abnormal studies in noncancer patients, 20% (2\/10) radiological leaks were found, but none of these patients had postoperative complications. Overall leak rates were 7% (29\/394), and rates were significantly higher in cancer patients than noncancer patients (10 <jats:italic>vs<\/jats:italic> 2%, <jats:italic>P<\/jats:italic> =\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Routine use of WSCE may not be necessary prior to reversal. WSCE should be selectively used in event of postoperative leak or complications. Noncancer resections are less likely demonstrate a leak.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12267","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T06:38:47Z","timestamp":1573108727000},"page":"417-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Is water\u2010soluble contrast enema examination for integrity of rectal anastomosis necessary prior to ileostomy reversal?"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-7637","authenticated-orcid":false,"given":"Hui Lu","family":"Goh","sequence":"first","affiliation":[{"name":"Heartlands Hospital University Hospitals Birmingham Foundation NHS Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Heartlands Hospital University Hospitals Birmingham Foundation NHS Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-0011","authenticated-orcid":false,"given":"Sivesh K","family":"Kamarajah","sequence":"additional","affiliation":[{"name":"Department of HPB and Transplant Surgery The Freeman Hospital  Newcastle upon Tyne UK"},{"name":"Institute of Cellular Medicine University of Newcastle  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharad","family":"Karandikar","sequence":"additional","affiliation":[{"name":"Heartlands Hospital University Hospitals Birmingham Foundation NHS Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Heartlands Hospital University Hospitals Birmingham Foundation NHS Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6627-9"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050158"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6694"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0708-x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-015-2225-7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-014-2113-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-016-3218-8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"e_1_2_5_10_1","first-page":"5710641","article-title":"Absence of association between preoperative estimated glomerular filtration rates and postoperative outcomes following elective gastrointestinal surgeries: a prospective cohort study","volume":"2018","author":"Kamarajah SK","year":"2018","journal-title":"Anesthesiol. Res. Pract."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-018-1849-9"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003242"},{"key":"e_1_2_5_13_1","first-page":"10","article-title":"Body composition assessment and sarcopenia in patients with pancreatic cancer: a systematic review and meta\u2010analysis","volume":"22","author":"Bundred J","year":"2019","journal-title":"HPB (Oxford)"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24908"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2018.01.001"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14828"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.11.055"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-018-1832-5"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2019.02.020"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs5.78"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-5810-x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-008-0407-9"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13704"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800691210"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2193-4"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-004-0652-y"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00360354"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-015-0742-z"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-008-0510-2"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12618"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02484627"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181612c6a"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-001-0256-4"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-007-0399-3"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2009.09.021"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0449-9"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00252-X"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(97)00018-5"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjgh3.12267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.12267","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T06:54:21Z","timestamp":1693983261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,6]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/jgh3.12267"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12267","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,6]]},"assertion":[{"value":"2018-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}