{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:35Z","timestamp":1786978055178,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>As the number of patients with eosinophilic esophagitis (EoE) has increased worldwide, the likelihood of diagnosing esophageal eosinophilia (EE) in screening endoscopy has also increased. Many of these EE patients do not display any symptoms (i.e. they display asymptomatic EE: aEE), and the risk of aEE patients developing EoE has yet to be demonstrated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 62\u2009250 cases were found in the endoscopic registries of two digestive disease centers in the context of gastric cancer screening from April 2016 to August 2018, and these were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010seven aEE patients (0.059%) were found in the registries, and the histories of endoscopic findings and symptoms were successfully traced for 29 of them. While 11 aEE (37.9%) patients did not show any change in endoscopic findings, 18 (62.1%) exhibited exacerbation. A comparison of the two groups showed both relative youth and diffuse disease distribution to be independent risk factors for progression (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0034 and 0.0078, respectively). Of the 18 aEE patients whose findings showed progression, 6 developed EoE (5 (17.2%) developed proton\u2010pump inhibitor (PPI)\u2010responsive EoE, and only 1 (3.4%) developed PPI\u2010resistant EoE). A comparison of the non\u2010EoE and EoE groups showed relative youth to be an independent risk factor for progression to EoE (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0146).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While some aEE patients developed symptomatic EE, the existence among them of PPI\u2010resistant EoE was extremely rare. Younger age and diffuse disease distribution at first detection in endoscopic findings are risk factors for progression to symptomatic EE in aEE patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.12270","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T08:48:40Z","timestamp":1570783720000},"page":"422-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Risk of progression to eosinophilic esophagitis in patients with asymptomatic esophageal eosinophilia: A retrospective pilot study"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4065-7958","authenticated-orcid":false,"given":"Fumiaki","family":"Ishibashi","sequence":"first","affiliation":[{"name":"Shinjuku Tsurukame Clinic Digestive Disease Center  Tokyo Japan"},{"name":"Koganei Tsurukame Clinic Endoscopic Center  Tokyo Japan"},{"name":"Department of Gastroenterology and Hepatology Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Shinjuku Tsurukame Clinic Digestive Disease Center  Tokyo Japan"},{"name":"Koganei Tsurukame Clinic Endoscopic Center  Tokyo Japan"},{"name":"Department of Gastroenterology and Hepatology Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Onizuka","sequence":"additional","affiliation":[{"name":"Shinjuku Tsurukame Clinic Digestive Disease Center  Tokyo Japan"},{"name":"Koganei Tsurukame Clinic Endoscopic Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Shinjuku Tsurukame Clinic Digestive Disease Center  Tokyo Japan"},{"name":"Koganei Tsurukame Clinic Endoscopic Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296781"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.017"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.71"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640616689525"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.11.006"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.11.019"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.62"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12091"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12706"},{"key":"e_1_2_5_12_1","first-page":"1","article-title":"Is asymptomatic esophageal eosinophilia the same disease entity as eosinophilic esophagitis?","volume":"17","author":"Ishimura N","year":"2018","journal-title":"Clin. 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