{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:08:16Z","timestamp":1789704496136,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) frequently overlap. However, no accepted treatment has yet been established for such patients. This study was conducted to identify an adequate initial treatment for patients with GERD accompanied by the postprandial distress syndrome type of FD (FD\u2010PDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of the 150 patients newly diagnosed with GERD who visited our clinic, 53 patients with the typical symptoms of both GERD and FD\u2010PDS were assessed using the modified frequency scale for the symptoms of GERD and the gastroesophageal reflux and dyspepsia therapeutic efficacy and satisfaction test questionnaires. Of those, 42 patients who completed 4\u2009weeks of treatment were analyzed. We compared the treatment responses between the 21 patients who received proton pump inhibitor (PPI) monotherapy and 21 patients who received a PPI in combination with the prokinetic drug acotiamide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Assessment of the two questionnaires revealed a marked improvement of both GERD and FD symptom scores after 4\u2009weeks of treatment in both groups. However, there were no significant differences in any GERD or FD symptom scores at baseline, after 4\u2009weeks of treatment and in the symptom score change between the two different treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this retrospective study suggest no benefit of PPI\u2010prokinetic combination <jats:italic>versus<\/jats:italic> PPI monotherapy in adult patients with FD\u2010GERD overlap; therefore, PPI monotherapy could be an adequate initial treatment for such patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12299","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T20:34:07Z","timestamp":1580762047000},"page":"582-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic strategy for the patients with coexisting gastroesophageal reflux disease and postprandial distress syndrome of functional dyspepsia"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-4083","authenticated-orcid":false,"given":"Kimio","family":"Isshi","sequence":"first","affiliation":[{"name":"Department of Gastoroenterology, Isshi Gastro\u2010Intestinal Clinic  Tokyo Japan"},{"name":"Department of Endoscopy Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Furuhashi","sequence":"additional","affiliation":[{"name":"Department of Gastoroenterology, Isshi Gastro\u2010Intestinal Clinic  Tokyo Japan"},{"name":"Department of Endoscopy Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nakada","sequence":"additional","affiliation":[{"name":"Department of Gastoroenterology, Isshi Gastro\u2010Intestinal Clinic  Tokyo Japan"},{"name":"Department of Laboratory Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701204204"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528509088842"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06249.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06632.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1227-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1022-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332404"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07121.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-015-1073-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i28.5216"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1417-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9178669"},{"key":"e_1_2_6_14_1","first-page":"CD002095","article-title":"Short\u2010term treatment with proton pump inhibitors, H2\u2010receptor antagonists and prokinetics for gastro\u2010oesophageal reflux disease\u2010like symptoms and endoscopy negative reflux disease","volume":"31","author":"Sigterman KE","year":"2013","journal-title":"Cochrane Database Syst. 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