{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:04:59Z","timestamp":1788966299930,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Esophagogastroduodenoscopy (EGD) is the gold standard tool in both screening\/diagnosis and management of varices in cirrhotic patients; however, its invasive nature may be uncomfortable to some patients, and in addition, it may be unavailable in some centers that cannot afford it. Therefore, to decrease the economic and physical burden on patients, multiple noninvasive clinical, laboratory, and radiological parameters are evaluated as triage screening predictors of varices before patients' referral to endoscopy. In this respect, we tried to evaluate the validity of portal vein velocity (PVV) as a noninvasive screening tool of esophageal varices (EV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred thirty\u2010five cirrhotic patients were consecutively enrolled in this cross\u2010sectional study. All patients were evaluated independently and blindly by EGD as the gold standard and then by Doppler ultrasound on portal vein (PV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Univariate regression showed significant coefficients for PVV, platelet (PLT), albumin, bilirubin, international normalized ratio (INR), portal vein diameter, and ascites; however, multivariable regression showed significant coefficients only for PVV, PLT, and albumin; (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.000, 0.000, and 0.006, respectively). Area under the receiver operating characteristic curve (AUROC), sensitivity, specificity, LR+, and LR\u2212 values were then calculated and validated using bootstrap analysis. PVV was more accurate than other evaluated parameters (AUROC: 0.927 and\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.000). The most accurate rule out cutoff value for PVV was \u226519\u2009cm\/s with the sensitivity of 97% and LR\u2212 of 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PVV may be useful as a noninvasive triage test for selection of the high\u2010risk cirrhotic patients who should be referred to and could benefit from EGD. We could highlight using PVV to rule out EV at a cutoff value \u226519\u2009cm\/s, reserving EGD only for patients with the PVV value &lt;19\u2009cm\/s.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.12301","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T01:54:21Z","timestamp":1579744461000},"page":"589-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Portal vein flow velocity as a possible fast noninvasive screening tool for esophageal varices in cirrhotic patients"],"prefix":"10.1002","volume":"4","author":[{"given":"Yara N","family":"Elkenawy","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reda A","family":"Elarabawy","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layla M","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4581-4908","authenticated-orcid":false,"given":"Abdallah A","family":"Elsawy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i31.5035"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2013.08.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50385"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01481.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-8320(05)88170-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24129"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04501.x"},{"key":"e_1_2_6_9_1","first-page":"376","article-title":"Non\u2010endoscopic predictors of large esophageal varices in patients with liver cirrhosis","volume":"49","author":"Chang MH","year":"2007","journal-title":"Korean J. 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