{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:28:42Z","timestamp":1790252922767,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The impact of hepatitis C virus (HCV) clearance by direct\u2010acting antiviral agents (DAAs) on HCV\u2010related extrahepatic manifestations is not well known. We evaluated the effect of viral clearance on metabolic and renal parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective study, HCV patients who achieved a sustained virologic response (SVR) by DAAs were evaluated before, at the end, and 24\u2009weeks after treatment for glycemic (serum glucose and insulin, HOMA\u2010IR, HOMA\u2010\u03b2, and HOMA\u2010S) and lipid (serum cholesterol, triglycerides, low\u2010density lipoprotein [LDL], high\u2010density lipoprotein) metabolism and renal function (serum creatinine, estimated glomerular filtration rate [eGFR]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 343 consecutive HCV patients were evaluated. At 24\u2009weeks of post\u2010follow\u2010up, an increase in body mass index (BMI) was observed (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Regardless of hepatic fibrosis levels and BMI, a reduction in serum glucose (<jats:italic>P<\/jats:italic> = 0.001), HOMA\u2010IR (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and HOMA\u2010\u03b2 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and an increase in HOMA\u2010S (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) values were observed at 24\u2009weeks after HCV clearance as compared to pretreatment values; 32.4% of patients with impaired fasting glucose normalized serum glucose values and 44.6% of diabetics showed an improvement in glycemic control. In contrast, serum cholesterol (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and LDL cholesterol (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) values were increased. Renal function was improved with about 10% reduction of serum creatinine values (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.02) and an increase of eGFR (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). A baseline eGFR of \u226460\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> was a negative predictor of renal function improvement. HCV clearance was an independent factor improving glucose metabolism and renal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study shows an occurrence of changes in metabolic and renal parameters in HCV patients with SVR, anticipating possible future clinical scenarios that the clinician must know for proper management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12324","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T18:45:24Z","timestamp":1584729924000},"page":"713-721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Metabolic and renal changes in patients with chronic hepatitis C infection after hepatitis C virus clearance by direct\u2010acting antivirals"],"prefix":"10.1002","volume":"4","author":[{"given":"Riccardo","family":"Nevola","sequence":"first","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Zeni","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando C","family":"Sasso","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia C","family":"Pafundi","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Guerrera","sequence":"additional","affiliation":[{"name":"Clinical Hospital of Marcianise, ASL Caserta  Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Marrone","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-4912","authenticated-orcid":false,"given":"Luigi 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