{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:18:21Z","timestamp":1776820701022,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is typically associated with metabolic syndrome and diabetes, and insulin resistance is involved in its pathogenesis. However, the relationship between insulin secretion and NAFLD is unclear. We aimed to characterize the relationship between fasting insulin secretory function (ISF), evaluated using the homeostatic model assessment\u2010beta cell function (HOMA\u2010\u03b2) and the severity of fibrosis during NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A\u2010\u03b2 was calculated in 188 patients with biopsy\u2010confirmed NAFLD, and the correlations between Log HOMA\u2010\u03b2 and clinical parameters, including hepatic fibrosis, were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Log HOMA\u2010\u03b2 was significantly lower in NAFLD patients with significant fibrosis (stages 2\u20134) than in those in the early stages (stages 0\u20131) (median [interquartile range]) (2.1 [1.9\u20132.4] <jats:italic>vs<\/jats:italic> 2.0 [1.8\u20132.2], <jats:italic>P<\/jats:italic> = 0.04). The prevalence of significant fibrosis decreased with increasing Log HOMA\u2010\u03b2: it was 59.2% in participants with low ISF (Log HOMA\u2010\u03b2\u2009&lt;\u20091.85), 43.6% in those with intermediate ISF (1.85\u2009\u2264\u2009Log HOMA\u2010\u03b2\u2009&lt;\u20092.25), and 68.0% in those with high ISF (Log HOMA\u2010\u03b2\u2009\u2265\u20092.25). Patients with lower Log HOMA\u2010\u03b2 had lower current body mass index (BMI), BMI at 20\u2009years of age, and peak lifetime BMI than patients with intermediate or high Log HOMA\u2010\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fasting ISF decreased alongside the development of liver fibrosis in NAFLD, suggesting that an impaired \u03b2 cell function has a characteristic finding of significant liver fibrosis in relatively nonobese Japanese patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12367","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T16:21:37Z","timestamp":1591719697000},"page":"929-936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Decrease in fasting insulin secretory function correlates with significant liver fibrosis in Japanese non\u2010alcoholic fatty liver disease patients"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-4441","authenticated-orcid":false,"given":"Norimasa","family":"Araki","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2374-2889","authenticated-orcid":false,"given":"Hirokazu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Takamori","sequence":"additional","affiliation":[{"name":"Clinical Research Center Saga University Hospital  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Saga 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