{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:36:41Z","timestamp":1789029401401,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Acute kidney injury increases mortality in cirrhotic patients by four fold. This study aimed to determine the usefulness of urinary neutrophil gelatinase\u2010associated lipocalin (uNGAL) for differential diagnosis for acute kidney injury and for predicting short\u2010term mortality in cirrhotic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 94 patients of decompensated cirrhosis. uNGAL was measured upon hospital admission in all patients. Patients with urinary tract infection and anuria were excluded. Patients were followed for 30\u2009days or until death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten (9%) patients had normal kidney function, 9 (11.37%) stable chronic kidney disease, 32 (29.50%) prerenal azotemia, 33 (36.37%) hepatorenal syndrome (HRS), and 10 (13.64%) intrinsic acute kidney injury (iAKI). Prerenal azotemia had lower median uNGAL values compared to HRS and iAKI (95.50 <jats:italic>vs<\/jats:italic> 465.00 <jats:italic>vs<\/jats:italic> 1217.50, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). uNGAL levels were significantly higher in patients who died within 30\u2009days (717.17\u2009\u00b1\u2009494.26 <jats:italic>vs<\/jats:italic> 331.65\u2009\u00b1\u2009313.65\u2009ng\/mL, <jats:italic>P<\/jats:italic> \u22120.0017). On univariate analysis, serum creatinine (sCr), uNGAL, Model for End\u2010Stage Liver Disease (MELD) score on admission, and length of stay were significant, and on multivariate analysis, uNGAL and hepatic encephalopathy (HE) were significant in predicting mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>uNGAL at baseline serves as an early marker in differentiating HRS, prerenal AKI, and iAKI in cirrhotic patients, where sCr values are not useful. Patients with higher uNGAL levels had higher transplant\u2010free mortality at 30\u2009days.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12377","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T18:20:14Z","timestamp":1593800414000},"page":"970-977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Urinary neutrophil gelatinase\u2010associated lipocalin determines short\u2010term mortality and type of acute kidney injury in cirrhosis"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-4833","authenticated-orcid":false,"given":"Suhas","family":"Udgirkar","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Topiwala National Medical College and B.Y.L Nair hospital Mumbai  Mumbai Maharashtra 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