{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:36:55Z","timestamp":1767908215938,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) initially presents as steatosis, which can progress to non\u2010alcoholic steatohepatitis (NASH), and often presents clinically alongside metabolic syndromes. Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) are regularly utilized to treat type 2 diabetes mellitus. The GLP\u20101 RA\u2014liraglutide\u2014ameliorates liver enzymes, histological features, and liver fat content of patients with NASH. However, few studies have examined whether the effect of GLP\u20101 RAs depends on changes in the patient's body mass index (BMI). Therefore, this retrospective study aimed to investigate whether the efficacy of liraglutide depended on the baseline BMI or a reduction in BMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010five Japanese patients with type 2 diabetes mellitus and NAFLD who received liraglutide treatment for 24\u2009weeks were assessed. The association between BMI and liver function or fibrosis was evaluated based on the aspartate aminotransferase, alanine aminotransferase, and fibrosis\u20104 indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 24\u2009weeks of liraglutide treatment improved liver function and fibrosis in patients with type 2 diabetes mellitus and NAFLD, regardless of BMI changes or obesity status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings provide important insight into the impact of BMI on liver function and fibrosis in patients with type 2 diabetes mellitus and NAFLD who are treated with liraglutide.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12384","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T18:21:50Z","timestamp":1593541310000},"page":"995-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Determining whether the effect of liraglutide on non\u2010alcoholic fatty liver disease depends on reductions in the body mass index"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3984-4134","authenticated-orcid":false,"given":"Megumi","family":"Shiomi","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy Kitasato University  Minato\u2010ku Japan"},{"name":"Department of Pharmacy Kitasato University Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy Kitasato University  Minato\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tesshu","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes, and Metabolism, School of Medicine Kitasato University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Otori","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy Kitasato University  Minato\u2010ku Japan"},{"name":"Department of Pharmacy Kitasato University Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12911"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.162"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0911-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2743-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23276"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1415-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00803-X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12856"},{"key":"e_1_2_8_11_1","first-page":"407","article-title":"Effect of liraglutide therapy on liver fat content in patients with inadequately controlled type 2 diabetes: The Lira\u2010NAFLD study","volume":"102","author":"Petit JM","year":"2017","journal-title":"J. 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