{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:55:55Z","timestamp":1768438555500,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>In patients with severe erosive reflux disease (ERD; Los Angeles classification grade C\/D) who do not undergo endoscopic examination, insufficient strength and duration of proton pump inhibitor (PPI) therapy may lead to complications such as esophageal bleeding and stenosis. Therefore, to provide a safe and effective treatment for gastroesophageal reflux disease (GERD), we investigated the clinical features of patients with severe ERD and their responses to PPI therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with GERD symptoms received PPI therapy for 4\u2009weeks after endoscopic examination. The patients completed the Gastroesophageal reflux and dyspepsia therapeutic efficacy and satisfaction test questionnaire before and 2 or 4\u2009weeks after PPI treatment. Patient characteristics, presence\/absence of coexisting atrophic gastritis (AG) and hiatus hernia (HH), and responses to PPI therapy were compared in patients with GERD among three groups (nonerosive reflux disease, mild ERD [grade A\/B], and severe ERD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The severe ERD group had a significantly higher proportion of males, higher body mass index, and longer duration of GERD morbidity. Furthermore, the severe ERD group also had a significantly lower incidence of coexisting AG and higher incidence of HH. There was no difference in the severity of GERD before PPI treatment among the three groups. Unexpectedly, the response to PPI therapy was the best in the severe ERD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sufficient strength and period of PPI therapy are required, even if the symptoms show early improvement, when treating GERD patients without performing endoscopy, considering the possibility of severe ERD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12455","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T05:47:01Z","timestamp":1607492821000},"page":"99-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical features and therapeutic responses to proton pump inhibitor in patients with severe reflux esophagitis: A multicenter prospective observational study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-4083","authenticated-orcid":false,"given":"Kimio","family":"Isshi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Isshi Gastro\u2010Intestinal Clinic  2\u201015\u201021, Shinozaki\u2010cho Edogawa\u2010Ku 133\u20100061 Tokyo Japan"},{"name":"Department of Endoscopy The Jikei University School of Medicine  3\u201015\u20108, Nishishinbashi Minato\u2010Ku 105\u20108461 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Matsuhashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology NTT Medical Center Tokyo  5\u20109\u201022, Higashi\u2010Gotanda Shinagawa\u2010Ku 144\u20108625 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Joh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Gamagori City Hospital  1\u20101, Mukaida Hirata\u2010cho Gamagori 443\u20108501 Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical College  2\u20107, Daigakumachi Takatsuki 569\u20108686 Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Iwakiri","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Graduate School of Medicine  1\u20101\u20105, Sendagi Bunkyo\u2010Ku 133\u20108603 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Medical Innovation Nagoya City University Graduate School Medical Sciences  1, Kwasumi Mizuhocho, Mizuho\u2010Ku Nagoya 467\u20108601 Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Manabe","sequence":"additional","affiliation":[{"name":"Division of Endoscopy and Ultrasonography, Department of Laboratory Medicine Kawasaki Medical School  2\u20106\u20101, Nakasange, Kita\u2010Ku Okayama 700\u20108505 Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Nakada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Katsushika Medical Center, The Jikei University School of Medicine  6\u201041\u20102, Aoto Katsushika\u2010Ku 125\u20108506 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Katsushika Medical Center, The Jikei University School of Medicine  6\u201041\u20102, Aoto Katsushika\u2010Ku 125\u20108506 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Arihiro","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Katsushika Medical Center, The Jikei University School of Medicine  6\u201041\u20102, Aoto Katsushika\u2010Ku 125\u20108506 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Haruma","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine 2 Kawasaki Medical School Kawasaki Hospital  577, Matsushima Kurashiki 701\u20100192 Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Nakada","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The Jikei University School of Medicine  3\u201025\u20108, Nishishinbashi Minato\u2010Ku 105\u20108461 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1227-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1775-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2157-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i2.318"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-015-1073-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i28.5216"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026179517081"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0276-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.0349"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-016-0558-0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2235-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0047-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023260"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1679-x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0429-3"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","unstructured":"YasuharaH MiyakeY ToyokawaTet al.Large waist circumference is a risk factor for reflux esophagitis in Japanese males Digestion.2010;81:181\u20137.","DOI":"10.1159\/000235919"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0671-3"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7241"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0649-1"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S114709"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i23.3558"},{"key":"e_1_2_6_25_1","first-page":"8S","article-title":"Aging, the gastrointestinal tract, and risk of acid\u2010related disease","volume":"117","author":"Greenwald DA","year":"2004","journal-title":"Am. J. Med."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.08.011"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283426f57"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0359-5"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065996"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133865"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02408.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9178669"},{"key":"e_1_2_6_33_1","first-page":"6","article-title":"Heartburn severity does not predict disease severity in patients with erosive esophagitis","volume":"8","author":"Fennerty MB","year":"2006","journal-title":"MedGenMed"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000007857.15694.15"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-9071-3"},{"key":"e_1_2_6_36_1","first-page":"741","article-title":"Rabeprazole is equivalent to omeprazole in the treatment of erosive gastro\u2010oesophageal reflux disease. A randomised, double\u2010blind, comparative study of rabeprazole and omeprazole 20 mg in acute treatment of reflux oesophagitis, followed by a maintenance open\u2010label, low\u2010dose therapy with rabeprazole","volume":"37","author":"Pace F","year":"2005","journal-title":"Dig. Liver Dis."},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655200453566"},{"key":"e_1_2_6_38_1","first-page":"245","article-title":"Pantoprazole versus lansoprazole in French patients with reflux esophagitis","volume":"25","author":"Dupas JL","year":"2001","journal-title":"Gastroenterol. Clin. Biol."},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00856.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03600.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3489-4"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03933.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13331"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02339.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.14-144"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.127637"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1996.56198000.x"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.12455","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T10:50:25Z","timestamp":1693306225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,8]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/jgh3.12455"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12455","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,8]]},"assertion":[{"value":"2020-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}