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These measures also inform economic evaluations by modelling quality\u2010adjusted life years (QALYs). We aimed to describe health\u2010related quality of life, specifically multiattribute utility (scale anchors of death = 0.00 and full health = 1.00), across various stages and etiologies of cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Face\u2010to\u2010face interviews were used to collect Short Form 36 (SF\u201036) questionnaire responses from CirCare study participants with cirrhosis (June 2017 to December 2018). The severity of cirrhosis was assessed using the Child\u2010Pugh score classified as class A (5\u20136 points), B (7\u20139), or C (10\u201315) and by the absence (\u201ccompensated\u201d) <jats:italic>versus<\/jats:italic> presence (\u201cdecompensated\u201d) of cirrhosis\u2010related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients (<jats:italic>n<\/jats:italic> =\u2009562, average 59.8\u2009years [SD = 11.0], male 69.9%) had a range of primary etiologies (alcohol\u2010related 35.2%, chronic hepatitis C 25.4%, non\u2010alcoholic fatty liver disease (NAFLD) 25.1%, chronic hepatitis B 5.9%, \u201cother\u201d 8.4%). Significantly lower (all <jats:italic>P<\/jats:italic> &lt;\u20090.001) mean multiattribute utility was observed in the health states of patients with decompensated (mean = 0.62, SD = 0.15) <jats:italic>versus<\/jats:italic> compensated cirrhosis (mean = 0.68, SD = 0.12), Child\u2010Pugh class C (mean = 0.59, SD = 0.15) or B (mean = 0.63, SD = 0.15) <jats:italic>versus<\/jats:italic> A (mean = 0.68, SD = 0.16), and between those of working age (18\u201364\u2009years; mean = 0.64, SD = 0.16) <jats:italic>versus<\/jats:italic> those aged 65+ years (mean = 0.70, SD = 0.16). The greatest decrements in health\u2010related quality of life relative to Australian population norms were observed across physical SF\u201036 domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Persons with more advanced cirrhosis report greater life impacts. Estimates from this study are suitable for informing economic evaluations, particularly cost\u2010utility modelling, which captures the benefits of effective prevention, surveillance, and treatments on both the quality and quantity of patients' lives.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12462","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T01:54:03Z","timestamp":1607651643000},"page":"133-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Assessment of health\u2010related quality of life and health utilities in Australian patients with cirrhosis"],"prefix":"10.1002","volume":"5","author":[{"given":"Steven M","family":"McPhail","sequence":"first","affiliation":[{"name":"Australian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work Queensland University of Technology  Brisbane Queensland 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