{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:18:55Z","timestamp":1753888735727,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Given the global health burden caused by the Coronavirus Disease 2019 (COVID\u201019), there have been numerous studies aimed to understand its clinical course and to determine risk factors that may impact prognosis. Pre\u2010existing medical conditions are linked with COVID\u201019 severity, particularly cardiometabolic diseases. Increasing evidence has also linked metabolic\u2010associated fatty liver disease (MAFLD) with severe COVID\u201019 illness. Thus, we review different published clinical data relating to the association of MAFLD and COVID\u201019 severity. Our review showed that published studies consistently support the association between MAFLD and more severe COVID\u201019, even after adjustment for confounding factors. It was also observed that an increasing hepatic fibrosis score is correlated with increasing severity of COVID\u201019. Finally, younger age and obesity among MAFLD patients also led to a greater risk of severe illness.<\/jats:p>","DOI":"10.1002\/jgh3.12465","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T22:57:01Z","timestamp":1606863421000},"page":"4-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of metabolic\u2010associated fatty liver disease and risk of severe coronavirus disease 2019 illness"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-2801","authenticated-orcid":false,"given":"Marianne Linley","family":"Sy\u2010Janairo","sequence":"first","affiliation":[{"name":"Institute of Digestive and Liver Diseases St. Luke's Medical Center Global City  Taguig Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian Homer","family":"Y Cua","sequence":"additional","affiliation":[{"name":"Institute of Digestive and Liver Diseases St. Luke's Medical Center Global City  Taguig Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Coronavirus (COVID\u201019) Events as They Happen. Cited 28 May 2020. Available from URL:https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/events-as-they-happen"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2648"},{"key":"e_1_2_5_4_1","first-page":"1775","article-title":"Case\u2010fatality rate and characteristics of patients dying in relation to COVID\u201019 in Italy","volume":"323","author":"Onder G","year":"2020","journal-title":"JAMA"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30243-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","unstructured":"Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID\u201019) \u2014 United States February 12\u2013March 16 2020.MMWR Morb. Mortal. Wkly. Rep. [Internet]. 2020;69: 343\u20136. Cited 4 June 2020. Available from URL:https:\/\/www.cdc.","DOI":"10.15585\/mmwr.mm6912e2"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05991-x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10072-8"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14583"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.044"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321611"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_2_5_15_1","article-title":"Metabolic associated fatty liver disease increases COVID\u201019 disease severity in non\u2010diabetic patients","author":"Gao F","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001902"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154244"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.027"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.05.005"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22859"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12365"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22350"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2020.05.001"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.04.021"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1592"},{"key":"e_1_2_5_26_1","first-page":"428","article-title":"Comment Liver injury in COVID\u201019: management and challenges","volume":"5","author":"Zhang C","year":"2020","journal-title":"Lancet"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.062398"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.035"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108427"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14484"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30190-4"},{"key":"e_1_2_5_32_1","first-page":"1087","article-title":"Diagnosis and treatment protocol for novel coronavirus pneumonia (Trial version 7)","volume":"133","author":"National Health Commission and National Health Commission & State Administration of Traditional Chinese Medicine","year":"2020","journal-title":"Chin. Med. J. (Engl.)"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.12465","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T10:51:39Z","timestamp":1693306299000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/jgh3.12465"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12465","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"type":"print","value":"2397-9070"},{"type":"electronic","value":"2397-9070"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"2020-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}