{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:41:55Z","timestamp":1787319715763,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>An elimination\u2010rechallenge dietary approach targeting naturally\u2010occurring bioactive chemicals has been proposed to alleviate functional gastrointestinal symptoms. A major focus of this approach is salicylates. This study aimed to address the potential role of dietary salicylates in the induction of symptoms in patients with irritable bowel syndrome (IBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A pilot, double\u2010blind, randomized, cross\u2010over trial of 2\u2010week low\u2010\n                      <jats:italic>versus<\/jats:italic>\n                      high\u2010salicylate diets (6.6 and 27.9\u00a0g\/day salicylate, respectively) was undertaken. All foods were provided containing minimal quantities of other potential food triggers. Gastrointestinal and extraintestinal symptoms were measured daily using a 100\u2010mm visual\u2010analogue\u2010scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten participants with IBS completed the study, including one with known aspirin\u2010sensitivity. Overall, no differences in symptoms were observed (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.625; Friedman test). However, clear symptom provocation was seen in the aspirin\u2010sensitive participant, with all abdominal symptoms and tiredness worsening during the high\u2010salicylate diet. A similar trend was seen in another participant, where abdominal symptoms gradually worsened during the high\u2010salicylate diet.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results provide some evidence that food\u2010related salicylates may influence the genesis of symptoms in a subset of patients with IBS. A larger cohort is needed to determine the incidence of salicylate\u2010sensitivity and further evaluate the diet as a potential therapeutic target.<\/jats:p>\n                    <jats:p>\n                      The protocol was registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.anzctr.org.au\">www.anzctr.org.au<\/jats:ext-link>\n                      (ACTRN12620001250921).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.12578","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T03:48:37Z","timestamp":1626839317000},"page":"871-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Naturally\u2010occurring dietary salicylates in the genesis of functional gastrointestinal symptoms in patients with irritable bowel syndrome: Pilot study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5343-7842","authenticated-orcid":false,"given":"Caroline J","family":"Tuck","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Alfred Hospital and Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreepurna","family":"Malakar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Alfred Hospital and Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline S","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Alfred Hospital and Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane G","family":"Muir","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Alfred Hospital and Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9108-1712","authenticated-orcid":false,"given":"Peter R","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Alfred Hospital and Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.105"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.09.046"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.010"},{"key":"e_1_2_6_5_1","volume-title":"RPAH Elimination Diet Handbook","author":"Swain AR","year":"2011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X11436241"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.037"},{"issue":"5","key":"e_1_2_6_8_1","first-page":"S37","article-title":"Adverse reactions to foods","volume":"141","author":"Allen D","year":"1984","journal-title":"Med. 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