{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:13:59Z","timestamp":1790100839722,"version":"4.0.1"},"reference-count":64,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sickle cell disorders are the most common hemoglobinopathies worldwide. Clinical variability of sickle cell disease (SCD) and susceptibility to its complications have been attributed to hematologic, genetic, and other influencing factors. This review aimed to provide further summary and analyses of the prevalence and factors associated with cholelithiasis among patients with SCD. A systematic database search was conducted in MEDLINE (PubMed), ScienceDirect, Google Scholar, World Health Organization Virtual Health Library, Cochrane Library databases, and System for Information on Gray Literature in Europe (SIGLE). Pooled prevalence, odds ratio (OR), and standardized mean difference (SMD) with the corresponding 95% confidence interval (CI) were calculated using Comprehensive Meta\u2010Analysis Software version 3.3. A total of 34 studies that fulfilled the eligibility criteria were included in the analyses. The overall prevalence of cholelithiasis among SCD patients was 25.3% (95% CI 19.4\u201332.3%). The risk of developing cholelithiasis was significantly associated with lower total hemoglobin level (SMD\u00a0=\u00a0\u22120.45; <jats:italic>P<\/jats:italic>\u00a0=\u20090.002), lower hemoglobin F (HbF) level (SMD\u00a0=\u00a0\u22120.85; <jats:italic>P<\/jats:italic>\u00a0=\u20090.003), higher total serum bilirubin level (SMD\u00a0=\u00a01.15; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001), higher reticulocytes count (SMD\u00a0=\u00a00.44; <jats:italic>P<\/jats:italic>\u00a0=\u20090.007), and UDP\u2010glucuronosyltransferase\u20101A1 enzyme (UGT1A1) promoter polymorphism. This review provides a comprehensive view of the high rate of cholelithiasis and its associated factors in SCD patients.<\/jats:p>","DOI":"10.1002\/jgh3.12622","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T14:27:18Z","timestamp":1628346438000},"page":"997-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Correlates of gallbladder stones among patients with sickle cell disease: A meta\u2010analysis"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-2397","authenticated-orcid":false,"given":"Sagad O O","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health, Faculty of Medicine University of Khartoum  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer A O","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Khartoum  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahlia A A","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Khartoum  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almigdad H M","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Khartoum  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652408786241375"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-251348"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011692"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13212"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-303773"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1765"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.08.021103"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)00872-3"},{"key":"e_1_2_6_10_1","unstructured":"Nationl Heart Lung and Blood Institute National Institute of Health.Evidence\u2010Based Management of Sickle Cell Disease \u2010 Expert Panel Report [Internet].2014. Available from URL:https:\/\/www.nhlbi.nih.gov\/sites\/default\/files\/media\/docs\/sickle-cell-disease-report%20020816_0.pdf"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24413"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v8.i3.108"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.02.016"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)90054-4"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2020.02.046"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182a44d74"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.07.708"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000242716.66878.23"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.08.041"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01864-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2019-0105"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsz100"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.12"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/50.2.73"},{"key":"e_1_2_6_29_1","first-page":"295","article-title":"Gallstones in Ghanaian children with sickle cell disease","volume":"24","author":"Darko R","year":"2005","journal-title":"West Afr. J. Med."},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1258\/004947506775598707"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2017.6952"},{"key":"e_1_2_6_32_1","first-page":"154","article-title":"Outcome of cholelithiasis in Sudanese children with Sickle Cell Anaemia (SCA) after 13years follow\u2010up","volume":"13","author":"Attalla BA","year":"2013","journal-title":"Afr. Health Sci."},{"key":"e_1_2_6_33_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4103\/1119-3077.146987","article-title":"Sickle cell disease clinical phenotypes in children from South\u2010Western, Nigeria","volume":"18","author":"Adegoke SA","year":"2015","journal-title":"Niger. J. Clin. Pract."},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.9734\/BJMMR\/2014\/8645"},{"key":"e_1_2_6_35_1","first-page":"121","article-title":"Genetic link with cholelithiasis among pediatric SCA Tunisian patients: Examples of UGT1A1, SLCO1A2 and SLCO1B1","volume":"21","author":"Chaouch L","year":"2016","journal-title":"Hematology"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojped.2015.53039"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.4103\/2278-9596.153146"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojped.2019.91008"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/NJM.NJM_53_20"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.12659\/PJR.899609"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.015"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-019-0899-3"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02041"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830030102"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032008000400010"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2017.1289325"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21264"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0521"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-017-0283-y"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12650"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2012.751033"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077681"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2015.060"},{"key":"e_1_2_6_54_1","first-page":"187","article-title":"Cholelithiasis in patients with paediatric sickle cell anaemia in a Saudi hospital","volume":"14","author":"Alhawsawi ZM","year":"2019","journal-title":"J. Taibah Univ. Med. Sc."},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojepi.2020.104028"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2010.02.005"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12838"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091481"},{"key":"e_1_2_6_59_1","first-page":"188","article-title":"Association of UGT1A1 polymorphism with prevalence and age at onset of cholelithiasis in sickle cell anemia","volume":"90","author":"Chaar V","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2012.6.2.172"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1615\/JLongTermEffMedImplants.v15.i3.90"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31823f5b1e"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181b99c72"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872002000400014"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v3.i7.599"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12622","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.12622","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T01:13:57Z","timestamp":1693358037000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,7]]},"references-count":64,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/jgh3.12622"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12622","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,7]]},"assertion":[{"value":"2021-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}