{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:11:32Z","timestamp":1775646692600,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Biliary tract infection (BTI) is an inflammatory disease and commonly associated with bacteremia. Delays in diagnosis or treatment of BTI cause high morbidity and mortality. However, an early diagnosis depends on appropriate clinical investigations. Appropriate biomarkers are urgently needed to improve the BTI diagnostic rate. We hypothesized that intestinal fatty acid\u2010binding protein (I\u2010FABP) might be a potential biomarker for BTI diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined data from subjects aged \u226518\u2009years diagnosed with BTI, including cholangitis and cholecystitis, whose blood samples were adequate for I\u2010FABP and zonulin assessment. We also collected blood samples from healthy volunteers as the control group. We excluded subjects in both groups who received steroids, antibiotics, or probiotics within 1\u2009month before hospital admission (BTI cohort) or participation in this research (controls). The main study endpoint was to compare the diagnostic ability of I\u2010FABP to detect BTI in comparison with high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) and zonulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study collected the data of 51 patients with BTI and 35 healthy subjects. The receiver operating characteristic (ROC) area under the curve (AUC) for I\u2010FABP was 0.884 (95% confidence interval [CI]: 0.814\u20130.954), numerically higher than that for hs\u2010CRP (0.880; 0.785\u20130.976) and zonulin (0.570; 0.444\u20130.697). We estimated that the optimal cutoff value of I\u2010FABP was 2.1\u00a0ng\/mL (sensitivity: 0.804; specificity: 0.829) for the diagnosis of BTI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, this study suggests that I\u2010FABP may be a potential alternative biomarker to hs\u2010CRP for diagnosing BTI. Further research should verify the use of I\u2010FABP as a marker for BTI diagnosis, but also for other inflammatory diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12644","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T07:56:48Z","timestamp":1629446208000},"page":"1160-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intestinal fatty <scp>acid\u2010binding<\/scp> protein is a biomarker for diagnosis of biliary tract infection"],"prefix":"10.1002","volume":"5","author":[{"given":"Yu\u2010Chieh","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Digestive Disease Xiamen Chang Gung Hospital  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Digestive Disease Xiamen Chang Gung Hospital  Xiamen China"},{"name":"Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital, Linkou Medical Center  Taoyuan City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Chieh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Xiamen Chang Gung Hospital  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung\u2010Ning","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Digestive Disease Xiamen Chang Gung Hospital  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Kai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Emergency Clinic Xiamen Chang Gung Hospital  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Shan","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Sleep Center, Xiamen Chang Gung Hospital  Xiamen 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