{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:13:44Z","timestamp":1790972024872,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Recent advances of direct\u2010acting antiviral drugs for hepatitis C virus (HCV) have dramatically improved the sustained virologic response (SVR) rate, but hepatocellular carcinoma (HCC) development rarely occurs even in patients who achieve an SVR. Wisteria floribunda agglutinin\u2010positive mac\u20102\u2010binding protein (WFA<jats:sup>+<\/jats:sup>\u2010M2BP) was recently developed as a noninvasive biomarker of liver fibrosis. However, the association between the WFA<jats:sup>+<\/jats:sup>\u2010M2BP level and HCC development after the achievement of an SVR is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We examined the association between WFA<jats:sup>+<\/jats:sup>\u2010M2BP and HCC development in 522 HCV patients who achieved an SVR (Interferon [IFN]\u2010based therapy, <jats:italic>n<\/jats:italic>\u00a0=\u2009228; IFN\u2010free therapy, <jats:italic>n<\/jats:italic>\u00a0=\u2009294). Multivariate analysis revealed that a high WFA<jats:sup>+<\/jats:sup>\u2010M2BP level at SVR week 24 after treatment (SVR24) (hazard ratio [HR]\u00a0=\u00a01.215, <jats:italic>P<\/jats:italic>\u00a0=\u20090.020), low platelet counts (HR\u00a0=\u00a00.876, <jats:italic>P<\/jats:italic>\u00a0=\u20090.037), and old age (HR\u00a0=\u00a01.073, <jats:italic>P<\/jats:italic>\u00a0=\u20090.012) were independent risk factors for HCC development regardless of the treatment regimen. Receiver operator characteristics curve analysis revealed that a WFA<jats:sup>+<\/jats:sup>\u2010M2BP level at SVR24 of \u22651.62 cut\u2010off index (COI) was the cut\u2010off value for the prediction of HCC development (adjusted HR\u00a0=\u00a012.565, 95% CI 3.501\u201345.092, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). The 3\u2010 and 5\u2010year cumulative incidences of HCC were 1% and 1.6% in patients with low WFA<jats:sup>+<\/jats:sup>\u2010M2BP at SVR24 (&lt;1.62 COI), and 4.7% and 12.5% in patients with high WFA<jats:sup>+<\/jats:sup>\u2010M2BP (\u22651.62 COI) were, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The assessment of liver fibrosis using the WFA<jats:sup>+<\/jats:sup>\u2010M2BP level at SVR24 is a useful predictor of HCC development after HCV eradication even in the IFN\u2010free therapy era.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12655","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T07:46:49Z","timestamp":1632210409000},"page":"1203-1209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Post\u2010treatment serum Wisteria floribunda agglutinin\u2010positive mac\u20102\u2010binding protein level is a useful predictor of hepatocellular carcinoma development after hepatitis C virus eradication"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-7283","authenticated-orcid":false,"given":"Shunsuke","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Tsuzura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daishi","family":"Kabemura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Yatagai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayato","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Genda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"World Health Organization.Hepatitis C fact Sheet World Health Organization.2017. 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