{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:21:42Z","timestamp":1747149702807,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The aim of the present study was to examine the lifestyle\u2010 and comorbidity\u2010related determinant factors of the prescription of proton pump inhibitors (PPIs) for patients in whom <jats:italic>Helicobacter pylori<\/jats:italic> has been eradicated, and to evaluate the relationship between PPI prescription and the severity of endoscopic esophagitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included patients who underwent <jats:italic>H. pylori<\/jats:italic> eradication from May 2012 to September 2016 at Saiseikai Karatsu Hospital. All patients received upper gastrointestinal endoscopy before <jats:italic>H. pylori<\/jats:italic> eradication. Patients with open peptic ulcers and\/or malignant diseases were excluded, and a final total of 389 patients were evaluated. Medical records were reviewed to determine the prescription of PPIs after <jats:italic>H. pylori<\/jats:italic> eradication, lifestyle\u2010related factors, and comorbidities. Lifestyle\u2010related factors were confirmed by a questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PPIs were administered to 124 of 389 patients (31.9%). The only lifestyle\u2010related risk factor for the prescription of PPIs after <jats:italic>H. pylori<\/jats:italic> eradication was older age (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Hypertension increased the prescription of PPIs (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.034). The prescription of PPIs was not influenced by the presence of grade A esophagitis, whereas the PPI prescription rate was significantly increased in patients with grades B\/C\/D endoscopic esophagitis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The grade of chronic gastritis before <jats:italic>H. pylori<\/jats:italic> eradication had no effect on the prescription of PPIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The lifestyle\u2010 and comorbidity\u2010related risk factors for the prescription of PPIs after <jats:italic>H. pylori<\/jats:italic> eradication were older age and hypertension, while mild endoscopic esophagitis had no influence on PPI prescription.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12666","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T11:40:54Z","timestamp":1636544454000},"page":"1284-1288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lifestyle\u2010 and comorbidity\u2010related factors for the prescription of proton pump inhibitors after <i>Helicobacter pylori<\/i> eradication in Japan"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2976-4456","authenticated-orcid":false,"given":"Furitsu","family":"Shimada","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Saiseikai Karatsu Hospital  Saga Japan"},{"name":"Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"},{"name":"International University of Health and Welfare  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyoshi","family":"Endo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Saiseikai Karatsu Hospital  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Takamori","sequence":"additional","affiliation":[{"name":"Division of Clinical Research Center Saga University Hospital  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Saiseikai Karatsu Hospital  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Saiseikai Karatsu Hospital  Saga Japan"},{"name":"Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimpei","family":"Shirai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Saiseikai Karatsu Hospital  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Kakiuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Akutagawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Node","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Yamanouchi","sequence":"additional","affiliation":[{"name":"International University of Health and Welfare  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"International University of Health and Welfare  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuma","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"International University of Health and Welfare  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Esaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1227-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05249.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01572-y"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.20-153"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510680"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.978815"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1031-9436"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000007857.15694.15"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320705"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490889"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12597"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311304"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319954"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70024-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2019.1671487"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.20-51"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0047-5"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-101021"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine1962.24.276"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506153"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8698230"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12776"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02223.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196848"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-45"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03454.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13763"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2018.01.012"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492492"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0953-6205(02)00090-0"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441667"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.12666","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T09:01:02Z","timestamp":1693213262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1002\/jgh3.12666"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12666","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"type":"print","value":"2397-9070"},{"type":"electronic","value":"2397-9070"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"2021-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}