{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T12:47:46Z","timestamp":1776602866569,"version":"3.51.2"},"reference-count":74,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liver cirrhosis is the final stage of chronic liver disease (CLD) and is associated with high morbidity and mortality. Various complications such as portal hypertension, ascites retention, hepatic encephalopathy, and hepatorenal syndrome deeply affect patient outcome. The most common tools to predict the outcome of a CLD patient include the following: assessing severity of portal hypertension; scoring systems such as the model of end\u2010stage liver disease and Child\u2013Pugh score and blood biomarkers related to complications and\/or survival rate. In this article, we summarize recent studies of noninvasive markers for predicting impending complications related to CLD and discuss the clinical value of currently available blood biomarkers based on evidence from the literature. In addition, noninvasive blood biomarker assays for different prognostic functions were validated on 113 liver cirrhosis patients at our institution using Kaplan\u2013Meier curve analysis to confirm that these markers can satisfactorily predict CLD\u2010related patient death.<\/jats:p>","DOI":"10.1002\/jgh3.12667","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T12:10:11Z","timestamp":1635595811000},"page":"1250-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Update on blood\u2010based biomarkers for chronic liver diseases prognosis: Literature review and institutional experience"],"prefix":"10.1002","volume":"5","author":[{"given":"Motoh","family":"Iwasa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6738-4382","authenticated-orcid":false,"given":"Ryuta","family":"Shigefuku","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0555-2707","authenticated-orcid":false,"given":"Akiko","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8012-8578","authenticated-orcid":false,"given":"Yasuyuki","family":"Tamai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60121-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1583202"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.024"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02691.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2020.1748010"},{"key":"e_1_2_6_7_1","article-title":"Fluid biomarkers for predicting the prognosis of liver cirrhosis","volume":"2020","author":"Chen SH","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607191015004476"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30840-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18447"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24412"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.08.050"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00017-0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070309"},{"issue":"5","key":"e_1_2_6_15_1","article-title":"Branched\u2010chain amino acids for people with hepatic encephalopathy","volume":"5","author":"Gluud LL","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1216-y"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.06.024"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13291"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2016.15502"},{"key":"e_1_2_6_20_1","first-page":"3074","article-title":"Value of the albumin\u2013bilirubin score in the evaluation of hepatitis B virus\u2010related acute\u2010on\u2010chronic liver failure, liver cirrhosis, and hepatocellular carcinoma","volume":"15","author":"Lei Q","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-015-0292-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-018-1500-9"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2017.10.008"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.03.017"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-3084(98)00003-6"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7571"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1350"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14619"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29113"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12473"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm4010085"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.06.004"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2021.1879000"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.03.018"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05908.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-011-9266-y"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29290"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.07.020"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1109"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26226-6"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2180-x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2021.01.002"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12564"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1037346"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14522"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149230"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12992"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1894-8"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12428"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S174267"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15215"},{"key":"e_1_2_6_52_1","first-page":"1137","article-title":"Magnetization transfer ratio values and proton MR spectroscopy of normal\u2010appearing cerebral white matter in patients with liver cirrhosis","volume":"22","author":"Rovira A","year":"2001","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.09.030"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12495"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.033"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)30874-9"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-016-9862-6"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13601"},{"key":"e_1_2_6_59_1","first-page":"486","article-title":"Bacterial translocation markers in liver cirrhosis","volume":"30","author":"Alexopoulou A","year":"2017","journal-title":"Ann. Gastroenterol."},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i20.2264"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13264"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2010.00991.x"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.030"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-015-0378-z"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17051727"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.03.002"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.18.10482"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16206-5"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2013.10.006"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/872152"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13230"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12212"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.10.023"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665109990267"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.7291-21"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.12667","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T09:01:25Z","timestamp":1693213285000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,30]]},"references-count":74,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1002\/jgh3.12667"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12667","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,30]]},"assertion":[{"value":"2021-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}