{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:59:59Z","timestamp":1792036799860,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Liver stiffness measurement (LSM) and spleen stiffness measurement (SSM@50\u2009Hz) using standard vibration\u2010controlled transient elastography (VCTE) have been studied as a noninvasive test for screening of gastroesophageal varices (GEV) in chronic liver disease (CLD). Recently, a novel spleen\u2010dedicated VCTE (SSM@100\u2009Hz) has been developed. We evaluated the diagnostic performance of SSM@100\u2009Hz, SSM@50\u2009Hz, LSM, and other noninvasive tests using esophagogastroduodenoscopy (EGD) as the reference as well as the correlation with hepatic venous pressure gradient (HVPG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 123 patients with CLD enrolled in this cross\u2010sectional study. SSM@100\u2009Hz, SSM@50\u2009Hz, and LSM were determined by VCTE. EGD and HVPG were performed within 12\u2009weeks before or after VCTE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GEV were present in 60 patients. Failure or suboptimal SSM were fewer at 100\u2009Hz (4.0%) than at 50\u2009Hz (17.7%). All SSM values obtained at 100\u2009Hz were lower than the 100\u2009kPa ceiling threshold, but 10 patients reached the 75\u2009kPa ceiling threshold for SSM@50\u2009Hz. SSM@100\u2009Hz was most accurate (area under the receiver operating characteristic [AUROC]\u00a0=\u00a00.944) for the diagnosis of GEV compared to SSM@50\u2009Hz, LSM, and scoring systems. AUROC of SSM@100\u2009Hz for diagnosis of high\u2010bleeding risk varices (HRV) was 0.941, which was significantly higher than that of SSM@50\u2009Hz (AUROC\u00a0=\u00a00.842, <jats:italic>P<\/jats:italic>\u00a0=\u20090.002). SSM@100\u2009Hz showed higher specificity (82.0%) for diagnosis of HRV than SSM@50\u2009Hz (specificity\u00a0=\u00a067.1%). SSM@100\u2009Hz was significantly correlated with HVPG (<jats:italic>r<\/jats:italic>\u00a0=\u20090.71, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel spleen\u2010dedicated VCTE examination can be used for noninvasive assessment of GEV and HVPG in CLD. Japan Registry of Clinical Trials Registry No. jRCTs032200119.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12689","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T12:49:26Z","timestamp":1639486166000},"page":"11-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Gastroesophageal varices evaluation using spleen\u2010dedicated stiffness measurement by vibration\u2010controlled transient elastography"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-6714","authenticated-orcid":false,"given":"Koki","family":"Nagai","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University Graduate School of Medicine  Yokohama Japan"},{"name":"Department of Gastroenterology Shin\u2010yurigaoka General Hospital  Kawasaki 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