{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T10:51:47Z","timestamp":1771671107722,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Beta blockers combined with endoscopic variceal band ligation (EVL) is the most effective means for the prevention of variceal rebleeding. No data are available on the efficacy of carvedilol in the secondary prophylaxis of variceal bleeding in hepatosplenic schistosomiasis. The aim of this study was to evaluate the efficacy and safety of carvedilol compared to propranolol as secondary prophylaxis of variceal bleeding in hepatosplenic schistosomiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, randomized study over a period of 14\u2009months from February 2019 to March 2020. All patients with portal hypertension due to schistosomiasis with at least one episode of variceal bleeding were included and randomized to the propranolol and carvedilol groups. EVL protocol was continued in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients were eligible and randomized to propranolol (<jats:italic>n<\/jats:italic>\u00a0=\u200930) and carvedilol (<jats:italic>n<\/jats:italic>\u00a0=\u200931) groups. There was no significant difference in hemorrhagic recurrence between the carvedilol (<jats:italic>n<\/jats:italic>\u00a0=\u20091) and propranolol (<jats:italic>n<\/jats:italic>\u00a0=\u20093) groups (3.33 vs 10%; <jats:italic>P<\/jats:italic>\u00a0=\u20090.30). At 4\u00a0months, there was a significant reduction in mean arterial pressure (\u22124.13\u2009mm Hg; 95% CI: \u22126.27 to \u22121.99; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05) and heart rate (\u221212.13\u2009bpm; 95% CI: \u221213.92 to \u221210.35; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05) in the carvedilol group. There was no significant difference between the groups on the mean difference in arterial pressure. One patient in the carvedilol group had breathing difficulty. There were no adverse events in the propranolol group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no significant difference in the efficacy between carvedilol and propranolol. Carvedilol may be an alternative to propranolol for secondary prophylaxis of variceal rebleeding in hepatosplenic schistosomiasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12721","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T09:23:26Z","timestamp":1646645006000},"page":"213-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Carvedilol <i>versus<\/i> propranolol in the prevention of variceal rebleeding in hepatosplenic schistosomiasis: Efficacy and safety"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5751-0373","authenticated-orcid":false,"given":"Chantelli Iamblaudiot","family":"Razafindrazoto","sequence":"first","affiliation":[{"name":"Unity of Gastroenterology University Hospital Joseph Raseta Befelatanana  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7812-196X","authenticated-orcid":false,"given":"Lova Dany Ella","family":"Razafindrabekoto","sequence":"additional","affiliation":[{"name":"Unity of Intensive Care University Hospital Andrainjato  Fianarantsoa Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4511-4584","authenticated-orcid":false,"given":"Domoina Harivonjy","family":"Hasina Laingonirina","sequence":"additional","affiliation":[{"name":"Unity of Gastroenterology University Hospital Joseph Raseta Befelatanana  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raveloson","family":"Raveloson","sequence":"additional","affiliation":[{"name":"Unity of Hepato\u2010Gastroenterology University Hospital Andrainjato  Fianarantsoa Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjaramalala Sitraka","family":"Rasolonjatovo","sequence":"additional","affiliation":[{"name":"Unity of Gastroenterology University Hospital Joseph Raseta Befelatanana  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3667-773X","authenticated-orcid":false,"given":"Andry Lalaina Rin\u00e0","family":"Rakotozafindrabe","sequence":"additional","affiliation":[{"name":"Unity of Gastroenterology University Hospital Joseph Raseta Befelatanana  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2754-3799","authenticated-orcid":false,"given":"Tovo Harimanana","family":"Rabenjanahary","sequence":"additional","affiliation":[{"name":"Unity of Gastroenterology University Hospital Joseph Raseta Befelatanana  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-4941","authenticated-orcid":false,"given":"Soloniaina H\u00e9lio","family":"Razafimahefa","sequence":"additional","affiliation":[{"name":"Unity of Hepato\u2010Gastroenterology University Hospital Andrainjato  Fianarantsoa Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rado Manitrala","family":"Ramanampamonjy","sequence":"additional","affiliation":[{"name":"Unity of Gastroenterology University Hospital Joseph Raseta Befelatanana  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"372","article-title":"Lutte contre la schistosomose: d\u00e9fi et perspective pour le XXIe si\u00e8cle","volume":"99","author":"TchuemTcheunt\u00e9 LA","year":"2006","journal-title":"Bull. Soc. Pathol. Exot."},{"key":"e_1_2_8_3_1","volume-title":"Schistosomiasis Progress Report. 2001\u20132011 and Strategic Plan 2012\u20132020","author":"WHO","year":"2012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1994.11812896"},{"key":"e_1_2_8_5_1","first-page":"191","article-title":"l'hypertension portale des schistosomoses: \u00ab une entit\u00e9 meurtri\u00e8re \u00bb","volume":"96","author":"Klotz F","year":"2003","journal-title":"Bull. Soc. Pathol. Exot."},{"key":"e_1_2_8_6_1","first-page":"22","article-title":"Schistosoma mansoni infestation rate evaluation by Kato Katz's Method in Haute Matsiatra Region (Madagascar) School Environment","volume":"5","author":"Rakotozafy JCR","year":"2016","journal-title":"Int. J. Prev. 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Gastroenterol."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001442"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12634"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840360612"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.327"},{"key":"e_1_2_8_22_1","first-page":"689","article-title":"Aspect \u00e9pid\u00e9miolo\u2010clinique et th\u00e9rapeutique des h\u00e9morragies digestives vues au CHU Tambohobe Fianarantsoa","volume":"6","author":"Rakotovao MA","year":"2016","journal-title":"Rev. Med. Madag."}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.12721","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:03:17Z","timestamp":1692964997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/jgh3.12721"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12721","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"2021-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}