{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:12:18Z","timestamp":1793121138497,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>This study aimed to investigate the relationship between the histological type of colorectal lymphoma and its endoscopic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed patients with primary colorectal lymphoma who were diagnosed using colonoscopy and biopsy specimens at the National Cancer Center Hospital, Tokyo, Japan. The lesions were macroscopically classified into the following types via colonoscopy: polypoid, ulcerative, multiple lymphomatous polyposis, diffuse, and mixed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 117 lesions were identified in 90 patients enrolled in this study. Of these, 59 (50%) were located in the ileocecal region, 23 (20%) in the rectum, 9 (8%) in the transverse colon, 8 (7%) in the sigmoid colon, 7 (6%) in the descending colon, and 4 (3%) in the ascending colon. Moreover, the most common histological subtypes were diffuse large B\u2010cell lymphoma (DLBCL) in 39 patients (43%) and mantle cell lymphoma (MCL) in 23 patients (26%), followed by follicular lymphoma (FL; 17%), mucosa\u2010associated lymphoid tissue (MALT) lymphoma (9%), peripheral T\u2010cell lymphoma\u2010NOS (2%), monomorphic epitheliotropic intestinal T\u2010cell lymphoma (MEITL; 2%), and Burkitt lymphoma (1%). More than half of the DLBCL (52%), MCL (52%), and MALT (56%) lymphomas were macroscopically classified as polypoid types. In contrast, FL lesions showed various macroscopic types. The majority of DLBCL (62%) and FL (78%) lesions were distributed in the ileocecal region. MCL lesions tended to be widely spread in various sites of the large intestine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Colorectal lymphomas showed macroscopically distinctive features depending on the histological type. Understanding the macroscopic classification of the lesions by colonoscopy and its distribution may be helpful in diagnosing the type of lymphoma and determining the malignant grade based on the histological types.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12738","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T07:48:16Z","timestamp":1649231296000},"page":"257-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Endoscopic features of colorectal lymphoma according to histological type"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2564-9781","authenticated-orcid":false,"given":"Tatsuo","family":"Yachida","sequence":"first","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Chuo City Tokyo Japan"},{"name":"Department of Gastroenterology and Neurology, Faculty of Medicine Kagawa University  Kita\u2010gun Kagawa Japan"},{"name":"Department of General Internal Medicine, Faculty of Medicine Kagawa University  Kita\u2010gun Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Chuo City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Chuo City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Chuo City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Kakugawa","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Chuo City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko Miyagi","family":"Maeshima","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Center Hospital  Chuo City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Center Hospital  Chuo City Tokyo Japan"},{"name":"Pathology and Clinical Laboratory Division JR Tokyo General Hospital  Shibuya City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Kushima","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Center Hospital  Chuo City Tokyo Japan"},{"name":"Department of Clinical Laboratory Medicine and Diagnostic Pathology Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensei","family":"Tobinai","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital  Chuo City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8508-827X","authenticated-orcid":false,"given":"Hideki","family":"Kobara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Faculty of Medicine Kagawa University  Kita\u2010gun Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Masugata","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Faculty of Medicine Kagawa University  Kita\u2010gun Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Faculty of Medicine Kagawa University  Kita\u2010gun Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Saito","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Chuo City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-002-1307-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480807400306"},{"key":"e_1_2_6_4_1","first-page":"305","article-title":"Primary intestinal lymphoma: clinical and therapeutic features of 32 patients","volume":"82","author":"Zinzani PL","year":"1997","journal-title":"Haematologica"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4081\/rt.2013.e23"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.18.3861"},{"key":"e_1_2_6_7_1","first-page":"80","article-title":"Lymphoma of the colon","volume":"21","author":"Romaguera J","year":"2005","journal-title":"Curr. 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