{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:31:16Z","timestamp":1783715476675,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["900181"],"award-info":[{"award-number":["900181"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, and cardiovascular diseases are the most common cause of death in NAFLD patients. The present study aimed to evaluate the possible relationship between the presence and severity of NAFLD and coronary artery disease (CAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted on 296 patients (122 men and 174 women, with mean age 54.10\u2009\u00b1\u20099.33\u2009years) referred to the catheterization laboratory of Imam Reza Hospital affiliated to the Mashhad University of Medical Sciences, Mashhad, Iran, for elective coronary angiography to investigate the presence and severity of CAD. Additionally, all patients underwent abdominal ultrasonography (USG) to detect NAFLD and its severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 296 patients, 187 (63.2%) had CAD and 160 (50.1%) had NAFLD. NAFLD patients had significantly higher prevalence of obesity (odds ratio [OR]\u00a0=\u00a01.047, 95% confidence interval [CI]\u00a0=\u00a01.002\u20131.094), hypertension (OR\u00a0=\u00a01.909, 95% CI\u00a0=\u00a01.027\u20133.55), hyperlipidemia (OR\u00a0=\u00a03.474, 95% CI\u00a0=\u00a01.862\u20136.482), and CAD (OR\u00a0=\u00a02.009, 95% CI\u00a0=\u00a01.100\u20133.669). The percentage of patients with normal vessels was higher in the non\u2010NAFLD group, followed by the group with mild and severe NAFLD (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). However, single\u2010 and multi\u2010vessel disease incidences among the non\u2010NAFLD, mild, and severe NAFLD groups were 36.1, 43.1, and 63.7%, respectively. Interestingly, the percentage of patients with two\u2010vessel stenosis was significantly higher in severe NAFLD patients than mild and non\u2010NAFLD patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence and severity of NAFLD were independently associated with CAD. Mild NAFLD was primarily observed among patients with normal and non\u2010obstructive coronary artery patients, while severe NAFLD was more frequent in extensive CAD patients with multi\u2010vessel disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12746","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T10:13:53Z","timestamp":1651054433000},"page":"330-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Relationship between the prevalence and severity of non\u2010alcoholic fatty liver disease and coronary artery disease: Findings from a cross\u2010sectional study of a referral center in northeast Iran"],"prefix":"10.1002","volume":"6","author":[{"given":"Arash","family":"Gholoobi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnoosh","family":"Gifani","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Gholoobi","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Akhlaghi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Health Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Pezeshki Rad","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-5095","authenticated-orcid":false,"given":"Vafa","family":"Baradaran Rahimi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/AITC201811060"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2016.07.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.052"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i47.8263"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2016.12.033"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27869"},{"key":"e_1_2_7_10_1","first-page":"16","article-title":"The most important causes of death in Iranian population; a retrospective cohort study","volume":"3","author":"Saadat S","year":"2014","journal-title":"Emergency"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00487.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35354"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.06.020"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_19"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-016-0212-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8489238"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.07.107"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001183"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12285"},{"key":"e_1_2_7_20_1","first-page":"376","article-title":"The relationship between nonalcoholic fatty liver disease and the severity of coronary artery disease in patients with metabolic syndrome","volume":"36","author":"Alper AT","year":"2008","journal-title":"Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir"},{"key":"e_1_2_7_21_1","first-page":"351","article-title":"Prevalence of non\u2010alcoholic fatty liver disease and its correlation with coronary risk factors in patients with type 2 diabetes","volume":"59","author":"Agarwal AK","year":"2011","journal-title":"J. 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