{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:08:13Z","timestamp":1778540893413,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Anastomotic leakage (AL) in colorectal resection and primary anastomosis is a common and feared complication. Fully covered self\u2010expandable metal stents (FCSEMSs) have been used for the treatment of AL. It is still unknown whether FCSEMSs affect anastomosis healing negatively by causing ischemia. In an animal study, we investigated the metabolic effects over a FCSEMS covering a stapled colon anastomosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven pigs were investigated using microdialysis after laparotomy, colon resection, and anastomosis with stent placement. Measurements were done at the proximal and distal ends of the anastomosis and at a reference catheter placed at the small intestine. Measurements of glucose, pyruvate, lactate, glycerol, and the lactate\/pyruvate ratio (L\/P) were carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lactate and L\/P were significantly higher at the oral part of the anastomosis, while glucose showed a small declining tendency. At the distal part of the anastomosis, glucose decreased significantly after the resection but did not reach zero. Lactate increased significantly whereas L\/P increased only slightly. Glycerol levels were stable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Colon resection caused initially hypermetabolism in the intestinal ends next to the resection site. This hypermetabolism neither deteriorated nor turned into ischemia during the initial postoperative course, but the start of hypoxemia could not be excluded during the study and after the placement of an FCSEMS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12747","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T05:39:17Z","timestamp":1651901957000},"page":"338-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fully covered self\u2010expandable metal stent placed over a stapled colon anastomosis in an animal model: A pilot study of colon metabolism over the stent"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-8001","authenticated-orcid":false,"given":"Ioannis","family":"Oikonomakis","sequence":"first","affiliation":[{"name":"Department of Surgery, Colorectal Unit, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel T","family":"Jansson","sequence":"additional","affiliation":[{"name":"Medical University of Gdansk  Gdansk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Skoog","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery and Institute of Medicine, Department of Molecular and Clinical Medicine Sahlgrenska University Hospital and Academy  Gothenburg Sweden"},{"name":"\u00d6rebro University and Sahlgrenska University, Faculty of Medicine and Health  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristofer F","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian D","family":"Meehan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal M","family":"H\u00f6rer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Colorectal Unit, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Uppsala\u2010\u00d6rebroR.Koloncancer 2019: Nationell kvalitetsrapport f\u00f6r \u00e5r 2019 fr\u00e5n Svenska Kolorektalcancerregistret Ume\u00e5: RCC Norr; 2020. 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