{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:21:55Z","timestamp":1747149715651,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is common in the United States and China. We compared prevalence of metabolic syndrome (MS), hepatic steatosis and fibrosis, and quantity and quality of body fat between American <jats:italic>versus<\/jats:italic> Chinese patients with NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>NAFLD patients were prospectively recruited from the University of Michigan Health System (UMHS) in the United States and Peking University Health Sciences Center (PUHSC) in China. All patients had baseline computed tomography (CT), laboratory tests and Fibroscan\u00ae controlled attenuation parameter (CAP) and liver stiffness measurement (LSM). Comparisons were made for overall cohorts and matched cohorts (matched for sex, age, and body mass index [BMI] category). Logistic regression was performed to identify independent predictors of moderate and severe steatosis and lack of advanced fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred and one American and One\u2010hundred and sixty Chinese patients were included. UMHS patients were older, with higher prevalence of MS, had higher LSM and CAP scores, and more fat in liver, visceral, subcutaneous, and muscle compartments than PUHSC patients. Differences in LSM, visceral fat Hounsfield unit, and subcutaneous fat area (SFA) persisted in the matched cohort. NAFLD patients with MS had significantly higher LSM, and more fat in liver, visceral, subcutaneous and muscle compartments than those without. Moderate or severe steatosis was independently associated with MS, visceral fat quality, and SFA, while the absence of advanced fibrosis was associated with Asian race and not having MS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>American patients with NAFLD had more liver fibrosis than Chinese patients despite having better quality visceral fat and after matching for age, sex, and BMI category.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12756","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T06:43:21Z","timestamp":1653374601000},"page":"519-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Metabolic abnormalities, liver and body fat in American <i>versus<\/i> Chinese patients with non\u2010alcoholic fatty liver disease"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6284-0150","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Peking University Hepatology Institute Peking University People's Hospital  Beijing China"},{"name":"Division of Gastroenterology and Hepatology University of Michigan  Ann Arbor Michigan USA"},{"name":"National Center for International Cooperation on Translational and Clinical Research Peking University Health Sciences Center  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace L","family":"Su","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan  Ann Arbor Michigan USA"},{"name":"GI Section VA Ann Arbor Healthcare System  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaza","family":"Sravanthi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5561-8746","authenticated-orcid":false,"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University Hepatology Institute Peking University People's Hospital  Beijing China"},{"name":"National Center for International Cooperation on Translational and Clinical Research Peking University Health Sciences Center  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7000-693X","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"National Center for International Cooperation on Translational and Clinical Research Peking University Health Sciences Center  Beijing China"},{"name":"Department of Radiology Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiying","family":"Rao","sequence":"additional","affiliation":[{"name":"Peking University Hepatology Institute Peking University People's Hospital  Beijing China"},{"name":"National Center for International Cooperation on Translational and Clinical Research Peking University Health Sciences Center  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai","family":"Wei","sequence":"additional","affiliation":[{"name":"Peking University Hepatology Institute Peking University People's Hospital  Beijing China"},{"name":"National Center for International Cooperation on Translational and Clinical Research Peking University Health Sciences Center  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5811-6845","authenticated-orcid":false,"given":"Anna S","family":"Lok","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1002\/hep.28431"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1002\/hep.30702"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1016\/j.amjmed.2018.02.002"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1161\/ATVBAHA.112.301009"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1002\/hep.30908"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1016\/j.cgh.2020.06.066"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.3390\/jcm7120562"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1002\/hep.24283"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1002\/hep4.1435"},{"unstructured":"The National Health Commission of the People' Republic of China.Criteria of weight for adults(WS\/T 428\u20102013). 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