{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:47:45Z","timestamp":1784958465603,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>This study aimed to clarify the efficacy and safety of oral semaglutide treatment in patients with non\u2010alcoholic fatty liver disease (NAFLD) complicated by type 2 diabetes mellitus (T2DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010arm, open\u2010label pilot study. Sixteen patients with NAFLD who received oral semaglutide for T2DM were included in the analysis. Oral semaglutide was initiated at a dose of 3\u00a0mg once daily, and the dose was sequentially increased to 7\u00a0mg at 4\u2009weeks and 14\u2009mg at 8\u2009weeks (maintenance dose) until the end of the 24\u2010week trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Body weight and levels of liver\u2010related biochemistry, plasma glucose, and hemoglobin A1c decreased significantly from baseline to 12\u2009weeks. These significant decreases were maintained until the end of the trial. Additionally, levels of the homeostasis model assessment\u2010insulin resistance and triglyceride significantly decreased at 24\u2009weeks. Controlled attenuation parameter (CAP) values significantly decreased from baseline to 24\u2009weeks. Changes in body weight were correlated with those in levels of alanine aminotransferase (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.52) and CAP (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.72). As for liver fibrosis markers, significant decreases from baseline to 24\u2009weeks in levels of the fibrosis\u20104 index, ferritin, and type IV collagen 7\u00a0s were found; however, the liver stiffness measurement did not significantly decrease. Most adverse events were grade 1\u20132 transient gastrointestinal disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral semaglutide treatment in patients with NAFLD complicated by T2DM improved impaired liver function, hypertriglyceridemia, insulin resistance, and hepatic steatosis, as well as improving diabetic status and reducing body weight.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12780","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T10:04:01Z","timestamp":1655373841000},"page":"503-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Efficacy and safety of oral semaglutide in patients with non\u2010alcoholic fatty liver disease complicated by type 2 diabetes mellitus: A pilot study"],"prefix":"10.1002","volume":"6","author":[{"given":"Taeang","family":"Arai","sequence":"first","affiliation":[{"name":"Division of Gastroenterology 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