{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:12Z","timestamp":1786978152598,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      There have been contradictory reports about the association between\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection and iron deficiency anemia (IDA). Based on the high frequency of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection in Cameroon, we have evaluated the frequency of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection as the cause of anemia, and IDA among dyspeptic patients in Cameroon.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This cross\u2010sectional study enrolled 842 dyspeptic patients (472 women and 370 men) in two reference hospitals in Douala\u2010Cameroon. Each participant gave a written consent, and the study was approved by the National Ethical Committee. Erythroid\u2010related indices and markers of iron deficiency (ID) measurement were done for each participant as well as\n                      <jats:italic>H. pylori<\/jats:italic>\n                      detection. Data were analyzed using SSPS statistical package.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of anemia, ID, IDA, and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection was 65.08%, 31.47%, 25.65%, and 80.88%, respectively.\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infected individuals had a significantly lower mean value of hemoglobin (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01), hematocrit (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.04), ferritin (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03) and coefficient of transferrin saturation (CTS) levels (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.04) and a significantly higher mean value of mean corpuscular hemoglobin concentration (MCHC) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02). Compared with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      non\u2010infected participants,\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infected patients were 1.2938 (95% confidence interval [CI]: 0.9087\u20131.8421), 1.1851 (95% CI: 0.8122\u20131.7292), and 1.5636 (95% CI: 1.0206\u20132.3953) times at higher risk to develop anemia, ID, and IDA, respectively. A significant relationship was found between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection and IDA (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.04 and 0.04 for crude and age\/sex\u2010adjusted, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection seems to be associated with anemia, and IDA among dyspeptic patients in our milieu.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.12787","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T05:47:45Z","timestamp":1657864065000},"page":"554-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Relationship between active\n                    <i>Helicobacter pylori<\/i>\n                    infection and anemia, iron deficiency, iron deficiency anemia: A cross\u2010sectional study in a\n                    <scp>sub\u2010Saharan<\/scp>\n                    setting"],"prefix":"10.1002","volume":"6","author":[{"given":"Bertrand B","family":"Eyoum Bille","sequence":"first","affiliation":[{"name":"Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science University of Dschang Dschang Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6447-1413","authenticated-orcid":false,"given":"Laure B","family":"Kouitcheu Mabeku","sequence":"additional","affiliation":[{"name":"Medical Microbiology Laboratory, Department of Microbiology, Faculty of Science University of Yaound\u00e9 I Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Iron Deficiency Anaemia Assessment, Prevention, and Control: A Guide for Programme Managers [Internet]","author":"World Health Organization\/United Nations Children's Fund (UNICEF)\/United Nations University","year":"2001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i22.2720"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S43493"},{"issue":"3","key":"e_1_2_10_5_1","first-page":"1","article-title":"Guidelines for the management of iron deficiency anaemia","volume":"46","author":"Goddard AF","year":"2000","journal-title":"Br. Soc. Gastroenterol. Gut"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00260-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(92)90258-S"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312023292303"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3146-1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.4644"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00617.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.25100\/cm.v34i.3.263","article-title":"Helicobacter pylori: patolog\u00eda y prevalencia en biopsias g\u00e1stricas en Colombia","volume":"34","author":"Bravo LE","year":"2003","journal-title":"Colomb. Med."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711133372007"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521003663670"},{"key":"e_1_2_10_16_1","first-page":"1924","article-title":"Effect of Helicobacter pylori eradication on iron deficiency","volume":"123","author":"Zhang ZF","year":"2010","journal-title":"Chin Med J"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"e_1_2_10_18_1","unstructured":"NgimgohNS.Impact ofHelicobacter Pyloriinfection on the gut microbiota of patients suffering from gastro\u2010duodenal disorders at the Bafoussam Regional Hospital [Dissertation]. Cameroon: University of Dschang 2020."},{"key":"e_1_2_10_19_1","unstructured":"Faujo NintewoueGF.Prevalence ofHelicobacter Pyloriinfection in patients suffering from gastric cancer [Dissertation]. Cameroon: University of Dschang 2019."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.1999.98066.x"},{"key":"e_1_2_10_21_1","first-page":"313","article-title":"Improvement of complete blood count in patients with iron deficiency anemia and Helicobacter pylori infection after the eradication of Helicobacter pylori","volume":"51","author":"Hacihanefioglu A","year":"2004","journal-title":"Hepato\u2010gastroenterology"},{"key":"e_1_2_10_22_1","volume-title":"Worldwide Prevalence of Anemia 1993\u20132005: WHO Global Database on Anemia","author":"World Health Organization","year":"2008"},{"key":"e_1_2_10_23_1","volume-title":"Investigation and Management of Iron Deficiency","author":"British Columbia Guidelines and Protocols Advisory Committee","year":"2010"},{"key":"e_1_2_10_24_1","first-page":"723","volume-title":"Medicine","author":"Wang J\u2010Y","year":"2010"},{"key":"e_1_2_10_25_1","unstructured":"Haute autorit\u00e9 de sant\u00e9 (HAS).Rapport d'\u00e9valuation: Examens du m\u00e9tabolisme du fer dans les carences choix des examens du m\u00e9tabolisme du fer en cas de suspicion de carence en fer. Service \u00e9valuation des actes professionnels mars 2011."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2003.t01-7-00159.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.21037\/aob.2018.05.04"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-016-0247-1"},{"key":"e_1_2_10_29_1","first-page":"133","article-title":"Prevalence and factors associated with anemia in pregnant women attending the General Hospital in Douala","volume":"25","author":"Tchente CN","year":"2016","journal-title":"Pan Afr. Med. J."},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2015-021"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306890"},{"key":"e_1_2_10_32_1","first-page":"881","article-title":"Prevalence and morphological types of anaemia and hookworm infestation in the medical emergency ward, Mulago Hospital, Uganda","volume":"99","author":"Mukaya JE","year":"2009","journal-title":"S Afr Med J"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2011.11.015"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-016-0028-x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0001-706X(94)00079-G"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1980.11687396"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/31.1.20"},{"key":"e_1_2_10_38_1","first-page":"647","article-title":"Analysis on the burden of iron deficiency anemia in Chinese residents in 2008","volume":"27","author":"Zhang J","year":"2011","journal-title":"Chin. J. Public Health"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188783"},{"key":"e_1_2_10_40_1","volume-title":"Enqu\u00eate D\u00e9mographique et de Sant\u00e9: Cameroun 2004. [Demographic Health Survey: Cameroon 2004]","author":"Institut National de la Statistique, Minist\u00e8re de la Planification, de la Programmation du D\u00e9veloppent et de l'Am\u00e9nagement du Territoire, ORC Macro","year":"2005"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3506(88)80013-1"},{"key":"e_1_2_10_42_1","unstructured":"National Institute of Statistics (Cameroon) and ICFCameroon DHS Summary Report NIS and ICF Rockville Maryland USA 2018."},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(99)90007-X"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078394"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1998.58.606"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3849-y"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00793.x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2018.02.001"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.17795\/zjrms-7935"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70192-1"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03686.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.7.6.885-888.2000"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj018"},{"key":"e_1_2_10_54_1","first-page":"292","article-title":"Seroprevalence of Helicobacter pylori in the adult population of Christchurch: risk factors and relationship to dyspeptic symptoms and iron studies","volume":"112","author":"Collett JA","year":"1999","journal-title":"N. Z. Med. J."},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12330"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.114700"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2002.02797.x"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i26.4166"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200007000-00012"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/tru044"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408419209114559"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199901000-00027"},{"key":"e_1_2_10_63_1","first-page":"1","article-title":"H. pylori may not be associated with iron deficiency anemia in patients with normal gastrointestinal tract endoscopy results","volume":"375915","author":"Saler T","year":"2014","journal-title":"Adv. Haematol."},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980009004789"},{"key":"e_1_2_10_65_1","first-page":"16","article-title":"The correlation between H. pylori infection with serum ferritin concentration and iron deficiency anemia","volume":"1","author":"Keramati MR","year":"2007","journal-title":"Int. J. Hematol. Oncol."},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03089.x"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12787","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.12787","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T01:44:55Z","timestamp":1727574295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":65,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/jgh3.12787"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12787","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,15]]},"assertion":[{"value":"2022-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}