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Besides, SARS\u2010CoV\u20102 can involve the gastrointestinal tract, resulting in sequelae such as diarrhea, abdominal pain, nausea, anorexia, vomiting, constipation, abdominal distension, acid reflux, and\/or gastrointestinal bleeding. Previous investigations point to SARS\u2010CoV\u20102 entry into enterocytes enhances by the angiotensin\u2010converting enzyme 2 (ACE2) receptors. Interestingly, ACE2 receptors are abundantly expressed in the gut, implying infection with SARS\u2010CoV\u20102 might occur through this route as well as in the respiratory tract. According to mounting evidence, SARS\u2010CoV\u20102 RNA has been identified in fecal specimens of patients with COVID\u201019 during and beyond the acute phase. In addition, studies have shown gut microbiome composition is altered in patients with PASC, hence, another putative mechanism linked to gastrointestinal symptoms is gut dysbiosis. The presence of the gut\u2010lung axis in COVID\u201019 might have major implications for disease pathogenesis and treatment. This review discussed the prevalence of gastrointestinal symptoms and pathophysiology underlying possible infection of the gut in patients with PASC. Also, SARS\u2010COV\u20102 induced NLRP3 inflammasome\u2010dependent inflammatory pathways are briefly addressed.<\/jats:p>","DOI":"10.1002\/jgh3.12811","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T07:10:52Z","timestamp":1661411452000},"page":"667-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Symptomatology and microbiology of the gastrointestinal tract in <scp>post\u2010COVID<\/scp> conditions"],"prefix":"10.1002","volume":"6","author":[{"given":"Mohamad","family":"Norouzi Masir","sequence":"first","affiliation":[{"name":"Student Research Committee School of Medicine, Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5122-1274","authenticated-orcid":false,"given":"Milad","family":"Shirvaliloo","sequence":"additional","affiliation":[{"name":"Infectious &amp; Tropical Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00465-w"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32656-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.686029"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14652"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26368"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22717"},{"key":"e_1_2_7_8_1","unstructured":"NICEOverview|COVID\u201019 rapid guideline: managing the long\u2010term effects of COVID\u201019|Guidance|NICE. 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