{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:40:38Z","timestamp":1758703238689,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Patients with gastroesophageal reflux disease (GERD) frequently also have functional dyspepsia (FD) symptoms, which impair their quality of life. However, the magnitude and characteristics of the effects of each symptom on daily life have been unclarified. Using multiple regression analysis, we aimed to clarify these questions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 290 patients from 29 institutions across Japan, in this prospective, observational study. Patients responded to three questionnaires (Gastroesophageal Reflux and Dyspepsia Therapeutic Efficacy and Satisfaction Test [GERD\u2010TEST], Hospital Anxiety and Depression Scale [HADS], and 8\u2010item Short\u2010Form Health Survey [SF\u20108]) before and after 4\u2009weeks of proton pump inhibitor treatment. Pearson correlation and multiple regression analyses were conducted between symptoms such as typical GERD, epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS) of FD, and aspects of daily life, namely, level of satisfaction with the daily life of GERD\u2010TEST, anxiety and depression score of HADS, and physical and mental component summary of SF\u20108.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pearson correlation analysis showed a significant correlation in all combinations between GERD\/FD\u2010EPS\/FD\u2010PDS symptoms and the nine aspects of daily life. However, multiple regression analysis results deviated from these results, with the most significant effects seen in the PDS\u2010symptom subscale (SS) on the five aspects of daily life, that is, dissatisfaction with eating, daily life\u2010SS, anxiety, depression, and mental component summary (MCS) whereas the significant effects in GERD\u2010SS on five aspects of daily life, that is, dissatisfaction for eating, anxiety, depression, physical component summary, and MCS, disappeared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dealing with co\u2010existing FD symptoms without overlooking them may be important in the management of GERD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12837","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T11:14:17Z","timestamp":1667646857000},"page":"886-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of the effects of individual symptoms of gastroesophageal reflux disease co\u2010existing functional dyspepsia on patients' daily lives: A prospective, observational study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7560-1260","authenticated-orcid":false,"given":"Tatsuya","family":"Nakada","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Katsushika Medical Center The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-4083","authenticated-orcid":false,"given":"Kimio","family":"Isshi","sequence":"additional","affiliation":[{"name":"Isshi Gastro\u2010Intestinal Clinic and Department of Endoscopy The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Matsuhashi","sequence":"additional","affiliation":[{"name":"Tokyo General Hospital, Gastroenterology Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5558-6104","authenticated-orcid":false,"given":"Katsuhiko","family":"Iwakiri","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Medical Innovation Nagoya City University Graduate School Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Manabe","sequence":"additional","affiliation":[{"name":"Division of Endoscopy and Ultrasonography, Department of Laboratory Medicine Kawasaki Medical School  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Joh","sequence":"additional","affiliation":[{"name":"Gamagori City Hospital  Gamagori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Oshio","sequence":"additional","affiliation":[{"name":"Faculty of Letters, Arts and Sciences Waseda University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Katsushika Medical Center The Jikei University School of Medicine  Tokyo 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