{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:31:04Z","timestamp":1780407064958,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"FAPESB","doi-asserted-by":"publisher","award":["SUS0029\/2014"],"award-info":[{"award-number":["SUS0029\/2014"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020326","name":"IDOR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Obliterative portal venopathy (OPV) is one of the causes of non\u2010cirrhotic portal hypertension. However, many aspects of OPV remain unclear, including the etiology, pathogenesis, and natural history. The aim of this study was to describe the clinical features of OPV in a series of patients in Brazil in whom OPV was diagnosed through liver biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010three consecutive adult patients with OPV were retrospectively selected as a case series based on histologic criteria, defined by the presence of at least portal fibrosis, phlebosclerosis, disappearance and\/or reduction of the caliber of portal vein branches, and exclusion of cirrhosis. Clinical and laboratory data were analyzed. Clinically significant portal hypertension was considered in the presence of esophageal varices and\/or ascites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of patients at diagnosis was 44.5\u2009\u00b1\u200911\u2009years, who were predominantly female (81%). Clinically significant portal hypertension was found in 28% of cases. The most frequent indication for liver biopsy was the elevation of liver enzymes, mostly \u03b3\u2010glutamyl transferase (GGT) in 76% of patients, averaging 222\u2009IU\/L (upper limit of normality up to 40\u2009IU\/L) and alanine aminotransferase (ALT) in 64%, mean 84\u2009IU\/L (38\u2009IU\/L). One\u2010third of our patients had exposure to medications, especially herbal medicines, at the time of enzymatic changes. Other risk factors highlighted were features of autoimmunity in 25% of patients or thrombophilia in 20%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OPV can be diagnosed even before the onset of portal hypertension, ALT elevation, and especially GGT elevation in most cases. Its etiology is not defined, but autoimmune diseases, thrombophilia, and the use of medications or herbal medicines may play a role.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12840","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T07:39:58Z","timestamp":1668670798000},"page":"904-909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Obliterative portal venopathy: A neglected and probably misdiagnosed disease with peculiar etiology in South America"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0988-9526","authenticated-orcid":false,"given":"Vin\u00edcius","family":"Nunes","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Department Hospital Universit\u00e1rio Prof Edgard Santos  Salvador Brazil"},{"name":"Medical School of the Federal University of Bahia\u2010Brasil  Salvador Brazil"},{"name":"IDOR  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz A R","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine of the Federal University of Bahia  Salvador Brazil"},{"name":"LPEM of the Instituto de Pesquisa Gon\u00e7alo Moniz\u2010FIOCRUZ  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana R","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine of the Federal University of Bahia  Salvador Brazil"},{"name":"LPEM of the Instituto de Pesquisa Gon\u00e7alo Moniz\u2010FIOCRUZ  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Medical School of the Federal University of Bahia\u2010Brasil  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gild\u00e1sio N","family":"Junior","sequence":"additional","affiliation":[{"name":"Medical School of the Federal University of Bahia\u2010Brasil  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I","family":"Schinoni","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department Hospital Universit\u00e1rio Prof Edgard Santos  Salvador Brazil"},{"name":"Medical School of the Federal University of Bahia\u2010Brasil  Salvador Brazil"},{"name":"Faculty of Medicine Medical School of the Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Bessone","sequence":"additional","affiliation":[{"name":"Hospital Provincial del Centenario University of Rosario School of Medicine  Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymundo","family":"Paran\u00e1","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department Hospital Universit\u00e1rio Prof Edgard Santos  Salvador Brazil"},{"name":"Medical School of the Federal University of Bahia\u2010Brasil  Salvador Brazil"},{"name":"IDOR  S\u00e3o Paulo Brazil"},{"name":"Faculty of Medicine Medical School of the Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2736-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30047-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12936"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-2803.202100000-48"},{"key":"e_1_2_7_6_1","volume-title":"Vigil\u00e2ncia da Esquistossomose Mansoni: diretrizes t\u00e9cnicas","author":"Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em Sa\u00fade, Departamento de Vigil\u00e2ncia das Doen\u00e7as Transmiss\u00edveis","year":"2014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.07.038"},{"key":"e_1_2_7_8_1","first-page":"163","article-title":"Non\u2010specific imunological abnormalities and association of autoimmune diseases in idiopathic portal hypertension","volume":"40","author":"Saito K","year":"1993","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-3018-x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30862"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.472"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.114363"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197408292910903"},{"key":"e_1_2_7_14_1","first-page":"932","article-title":"Hepatoportal sclerosis related to the use of herbal and nutritional supplements. 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