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Diagnostic testing and treatment for\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection is recommended in patients with active or past history of peptic ulcer, chronic dyspepsia, chronic non\u2010steroidal anti\u2010inflammatory drugs (NSAID) or aspirin use, precancerous gastric lesions, gastric cancer, mucosa\u2010associated lymphoid tissue (MALT) lymphoma, family history of gastric cancer, family history of peptic ulcers, household family member having active\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection, iron deficiency anemia, idiopathic thrombocytopenic purpura, or vitamin B12 deficiency. Recommended first\u2010line regimens for\n                    <jats:italic>H. pylori<\/jats:italic>\n                    eradication are classified according to clarithromycin resistance. In areas of high clarithromycin resistance (\u226515%), we recommend 14\u2010day concomitant therapy or 14\u2010day bismuth quadruple therapy (BQT) as first\u2010line regimen. In areas of low clarithromycin resistance (&lt;15%), we recommend 14\u2010day triple therapy or 14\u2010day BQT as first\u2010line treatment. Second\u2010line regimens are 14\u2010day levofloxacin triple therapy or 14\u2010day BQT if BQT is not previously used. For patients with multiple treatment failure, antimicrobial susceptibility testing (AST) should be performed. If AST is not available, we recommend using antibiotics not previously used or for which resistance is unlikely, such as amoxicillin, tetracycline, bismuth, or furazolidone. High\u2010dose potent proton pump inhibitor or vonoprazan is recommended to achieve adequate acid suppression. Probiotics can be used as an adjuvant treatment to reduce the side effects of antibiotics and enhance eradication rate.\n                  <\/jats:p>","DOI":"10.1002\/jgh3.12843","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T01:39:36Z","timestamp":1669081176000},"page":"3-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Management of\n                    <i>Helicobacter pylori<\/i>\n                    infection"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6496-0284","authenticated-orcid":false,"given":"Natsuda","family":"Aumpan","sequence":"first","affiliation":[{"name":"Center of Excellence in Digestive Diseases and Gastroenterology Unit, Department of Medicine Thammasat University  Pathumthani Thailand"},{"name":"Department of Medicine Chulabhorn International College of Medicine (CICM) at Thammasat University  Pathumthani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varocha","family":"Mahachai","sequence":"additional","affiliation":[{"name":"Center of Excellence in Digestive Diseases and Gastroenterology Unit, Department of Medicine Thammasat University  Pathumthani Thailand"},{"name":"Department of Medicine Chulabhorn International College of Medicine (CICM) at Thammasat University  Pathumthani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4298-9331","authenticated-orcid":false,"given":"Ratha\u2010korn","family":"Vilaichone","sequence":"additional","affiliation":[{"name":"Center of Excellence in Digestive Diseases and Gastroenterology Unit, Department of Medicine Thammasat University  Pathumthani Thailand"},{"name":"Department of Medicine Chulabhorn International College of Medicine (CICM) at Thammasat University  Pathumthani Thailand"},{"name":"Division of Gastroentero\u2010Hepatology, Department of Internal Medicine, Faculty of Medicine Universitas Airlangga  Surabaya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_20_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.007"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13911"},{"key":"e_1_2_20_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.11.059"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.012"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_20_12_1","unstructured":"FerlayJ ErvikM LamFet al.Global cancer observatory: cancer today. 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