{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:22:10Z","timestamp":1747149730880,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The efficacy of sofosbuvir (SOF)\u2010based regimens in the treatment of chronic hepatitis C (HCV) patients with and without human immunodeficiency virus (HIV) co\u2010infected patients in real\u2010world setting is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study, conducted between 1 January 2017 and 31 December 2021 at Bamrasnaradura Infectious Disease Institute, Thailand. All HCV patients received 12\u2009weeks of SOF\u2010based regimens and had follow\u2010up for at least 12\u2009weeks after therapy discontinuation. The primary outcome was sustained virological response (SVR) at 12\u2009weeks after the end of treatment. Treatment outcomes were compared between HCV patients with and without HIV co\u2010infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 163 patients were included in the study, 130 (79.8%) were HCV\/HIV co\u2010infected, and 33 (20.2%) were HCV mono\u2010infected. Of all, 106 (64%) patients received SOF and ledipasvir. Genotype 1 (GT1) was predominant at 66.4%, followed by GT3 at 22.2%, and GT6 at 11.4%. Overall SVR was 96.9%. SVR in HCV mono\u2010infected was 96.9% and SVR in HIV\u2010HCV co\u2010infected patients was 96.9%. The factor associated with SVR was HCV genotype (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Patients with HCV GT6 had lower SVR rates compared with GT1 and GT3 patients (83.3%, 100%, and 97.1% [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.000] respectively). There was no association between SVR and other factors such as gender, age, BMI, underlying cirrhosis, baseline HCV viral load, or prior treatment history (all <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). All patients completed 12\u2010week SOF\u2010based treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In real\u2010world setting, HCV treatment with SOF\u2010based regimens between patients with and without HIV co\u2010infection showed high rates of SVR. SOF\u2010based regimens were highly efficacious and tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12869","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T07:29:03Z","timestamp":1674804543000},"page":"157-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010world treatment outcomes of sofosbuvir\u2010based regimens for treatment of chronic hepatitis C with and without human immunodeficiency virus co\u2010infection"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3014-4852","authenticated-orcid":false,"given":"Suparat","family":"Khemnark","sequence":"first","affiliation":[{"name":"Department of Medicine Bamrasnaradura Infectious Disease Institute, Ministry of Public Health  Nonthaburi Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weerawat","family":"Manosuthi","sequence":"additional","affiliation":[{"name":"Department of Medicine Bamrasnaradura Infectious Disease Institute, Ministry of Public Health  Nonthaburi Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30181-9"},{"key":"e_1_2_5_3_1","first-page":"S79","article-title":"Risk factors of hepatitis C virus infection in blood donors in Thailand: a multicenter case\u2010control study","volume":"89","author":"Tanwandee T","year":"2006","journal-title":"J. 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