{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:34:38Z","timestamp":1775540078884,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Obtaining endoscopic biopsies from the ampulla of Vater is important for the diagnosis of lesions that are suspicious for neoplasia. The clinical safety profile is not well defined in the literature. Our aim was to evaluate the procedure\u2010related readmission rate and complications from ampullary biopsy in patients undergoing duodenoscopy and endoscopic retrograde cholangiopancreatography (ERCP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective data analysis was performed on adult patients at Austin Hospital who underwent ampullary biopsies between 1 January 2010 and 1 March 12022. Medical records were identified using pathology databases. The electronic health record was reviewed for baseline characteristics including demographics, date, indication for ampullary biopsy, procedure type (duodenoscopy or ERCP), and procedural associated interventions during ERCP. Readmissions to the Austin Emergency Department within 30\u2009days following the biopsy were identified, and complications were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 506 records were reviewed and 246 episodes of ampullary biopsy met the inclusion criteria. The procedure\u2010related readmission rate for all episodes was 6.1%, which included pain (3.3%), pancreatitis (2.0%), cholangitis (1.6%), and bleeding (0.8%). Ampullary biopsies with ERCP had a procedure\u2010related readmission rate of 8.4%, whereas ampullary biopsies without ERCP had a rate of 2.2%. Increased readmissions and complications were associated with male sex (<jats:italic>P<\/jats:italic>\u2009=\u20090.01 and <jats:italic>P<\/jats:italic>\u2009=\u20090.05, respectively). There was no association between the number of biopsies taken and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Performing an ampullary biopsy without an associated ERCP carries a low rate of clinical complications and procedure\u2010related readmissions. The combination of ERCP and ampullary biopsy increases the risk four\u2010fold.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12895","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T06:54:10Z","timestamp":1680072850000},"page":"299-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Readmission rate and complications following biopsy of the ampulla of Vater\u2014A retrospective data analysis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8481-9376","authenticated-orcid":false,"given":"Sam","family":"Rosella","sequence":"first","affiliation":[{"name":"Medicine, Dentistry and Health Sciences University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Zorron Cheng Tao Pu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Austin Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Austin Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0792-3265","authenticated-orcid":false,"given":"Kim Hay","family":"Be","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Austin Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhys","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Medicine, Dentistry and Health Sciences University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Gastroenterology and Hepatology Austin Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujievvan","family":"Chandran","sequence":"additional","affiliation":[{"name":"Medicine, Dentistry and Health Sciences University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Gastroenterology and Hepatology Austin Health  Melbourne Victoria Australia"},{"name":"Department of Medicine Monash University, Peninsula Health Campus  Frankston Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marios","family":"Efthymiou","sequence":"additional","affiliation":[{"name":"Medicine, Dentistry and Health Sciences University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Gastroenterology and Hepatology Austin Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Anatomy, Abdomen and Pelvis, Biliary Ducts","author":"Hundt M","year":"2021"},{"key":"e_1_2_5_3_1","first-page":"277","article-title":"Endoscopic retrograde cholangiopancreatography with ampullary biopsy vs ERCP alone: a matched\u2010pairs controlled evaluation of outcomes and complications","volume":"5","author":"Dacha S","year":"2017","journal-title":"Gastroenterol. Rep. (Oxf.)."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890701)64:1<161::AID-CNCR2820640127>3.0.CO;2-D"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(84)72357-1"},{"key":"e_1_2_5_6_1","first-page":"502","article-title":"Complications of elective esophago\u2010gastro\u2010duodenoscopy (EGDS). Personal experience and literature review","volume":"30","author":"Geraci G","year":"2009","journal-title":"G. Chir."},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260350032023"},{"key":"e_1_2_5_8_1","first-page":"1227","article-title":"Austrian benchmarking project for ERCP: a 10\u2010year report","volume":"56","author":"Kienbauer M","year":"2018","journal-title":"Z. 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