{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:34:39Z","timestamp":1788561279496,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Sarcopenia and severe vitamin D deficiency are associated with malnutrition and poor prognosis. We investigated the impact of the comorbidity of Child\u2013Pugh (CP) class B\/C cirrhosis and the aforementioned complications on the prognosis of patients with cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated 104 patients with cirrhosis. The cumulative survival rates were compared between patients with and without both or either of these disease conditions: CP class B\/C and complications (sarcopenia or severe vitamin D deficiency). Sarcopenia was diagnosed according to the Japan Society of Hepatology criteria. Severe vitamin D deficiency was defined as levels of 25\u2010hydroxyvitamin D &lt;10\u2009ng\/mL in serum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of CP class B\/C, sarcopenia, and severe vitamin D deficiency was 26.9%, 38.5%, and 24.0%, respectively. Patients with both CP class B\/C and sarcopenia had significantly lower survival rates than those without both (hazard ratio [HR] =\u20096.101; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and with either condition (HR\u2009=\u20096.137; <jats:italic>P<\/jats:italic>\u2009=\u20090.001). Similarly, patients with both CP class B\/C and severe vitamin D deficiency or with either condition had significantly lower survival rates than those without both conditions (HR\u2009=\u20098.135 or 3.189; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 or =0.025, respectively). CP class B\/C (HR\u2009=\u20093.354; <jats:italic>P<\/jats:italic>\u2009=\u20090.006) and severe vitamin D deficiency (HR\u2009=\u20092.445; <jats:italic>P<\/jats:italic>\u2009=\u20090.044) were independent prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The coexistence of CP class B\/C and sarcopenia or severe vitamin D deficiency worsened the prognosis of patients with cirrhosis. Nutritional assessments such as sarcopenia and vitamin D status should be considered to better evaluate disease conditions and patient prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12900","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T13:04:59Z","timestamp":1681477499000},"page":"351-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prognostic significance of sarcopenia and severe vitamin D deficiency in patients with cirrhosis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-6142","authenticated-orcid":false,"given":"Chisato","family":"Saeki","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"},{"name":"Division of Gastroenterology, Department of Internal Medicine Fuji City General Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Kanai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"},{"name":"Division of Gastroenterology, Department of Internal Medicine Fuji City General Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Ueda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8067-7297","authenticated-orcid":false,"given":"Masanori","family":"Nakano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"},{"name":"Division of Gastroenterology, Department of Internal Medicine Fuji City General Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-5391","authenticated-orcid":false,"given":"Tsunekazu","family":"Oikawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2349-8855","authenticated-orcid":false,"given":"Yuichi","family":"Torisu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"},{"name":"Division of Gastroenterology, Department of Internal Medicine Fuji City General Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Saruta","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6860-0326","authenticated-orcid":false,"given":"Akihito","family":"Tsubota","sequence":"additional","affiliation":[{"name":"Research Center for Medical Science The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30349-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020540"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12999"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2983-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12774"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32049"},{"key":"e_1_2_6_10_1","article-title":"Influencing factors and molecular pathogenesis of sarcopenia and osteosarcopenia in chronic liver disease","volume":"11","author":"Saeki C","year":"2021","journal-title":"Life (Basel)"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.07.005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12333"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12797"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13698"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8060319"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02735.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13485"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123810"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11456"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.024"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5852"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29913"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13679"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155357"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13816"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.715795"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.7326\/M21-3324"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12731"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-016-1127-1"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132119"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051248"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.07.026"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T15:43:01Z","timestamp":1692546181000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,14]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/jgh3.12900"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12900","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,14]]},"assertion":[{"value":"2023-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}