{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:22:15Z","timestamp":1747149735984,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>There is limited research on the use of histamine\u2010H2 receptor antagonists and proton pump inhibitors for treating COVID\u201019. We compare clinical outcomes between patients hospitalized with COVID\u201019 receiving famotidine or pantoprazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 2184 patients (famotidine: <jats:italic>n<\/jats:italic>\u2009=\u2009638, pantoprazole: <jats:italic>n<\/jats:italic>\u2009=\u2009727, nonuse: <jats:italic>n<\/jats:italic>\u2009=\u2009819) aged 18\u2009years or older treated for COVID\u201019 from March 2020 to March 2021. Patients who received both famotidine and pantoprazole treatments were excluded. Multivariate logistic regression was used for the primary outcome, namely all\u2010cause mortality, and the secondary outcomes, namely mechanical ventilation, vasopressor use, acute kidney injury, and gastrointestinal bleeding. The main predictor variable was the use of famotidine or pantoprazole. Covariates were demographics, chronic diseases, and symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As compared to nonuse, famotidine (OR: 0.30, 95% CI: 0.20\u20130.44, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and pantoprazole (OR: 0.47, 95% CI: 0.33\u20130.66, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were significantly associated with lower odds for all\u2010cause mortality. Comparison of famotidine and pantoprazole showed that the former had lower odds for all\u2010cause mortality (OR: 0.65, 95% CI:0.45\u20130.95, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), mechanical ventilation (OR: 0.38, 95% CI: 0.25\u20130.58, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), vasopressor use (OR: 0.33, 95% CI: 0.22\u20130.48, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), acute kidney injury (OR: 0.40, 95% CI: 0.30\u20130.54, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and gastrointestinal bleeding (OR: 0.15, 95% CI: 0.08, 0.29, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Famotidine is associated with lower odds for all\u2010cause mortality, mechanical ventilation, vasopressor use, acute kidney injury, and gastrointestinal bleeding as compared to pantoprazole in patients hospitalized with COVID\u201019. We recommend that clinicians consider the use of famotidine over pantoprazole for hospitalized COVID\u201019 patients. Future research with a clinical trial would be beneficial to further support such use of famotidine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12905","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T04:44:46Z","timestamp":1689050686000},"page":"464-469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A retrospective analysis of clinical outcomes between hospitalized patients with <scp>COVID<\/scp>\u201019 who received famotidine or pantoprazole"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-4834","authenticated-orcid":false,"given":"Justin J.","family":"Wagner","sequence":"first","affiliation":[{"name":"Department of Medicine South Brooklyn Health  Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolas","family":"St. Cyr","sequence":"additional","affiliation":[{"name":"Department of Medicine South Brooklyn Health  Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Douen","sequence":"additional","affiliation":[{"name":"Department of Medicine South Brooklyn Health  Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Fogel","sequence":"additional","affiliation":[{"name":"Department of Business Management  Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Trillo","sequence":"additional","affiliation":[{"name":"Department of Medicine South Brooklyn Health  Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization. (2023).WHO Coronavirus Disease (COVID\u201019) dashboard. Available from:https:\/\/covid19.who.int\/Accessed 16 Jan 2023."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000620"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.02.008"},{"key":"e_1_2_6_5_1","first-page":"9","article-title":"Mast cells contribute to coronavirus\u2010induced inflammation: new anti\u2010inflammatory strategy","volume":"34","author":"Kritas SK","year":"2020","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"e_1_2_6_6_1","first-page":"10.21203\/rs.3.r","article-title":"Broad\u2010spectrum inhibition of coronavirus main and papain\u2010like proteases by HCV drugs","author":"Anson BJ","year":"2020","journal-title":"Res. Sq."},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","unstructured":"BorrellB.New York clinical trial quietly tests heartburn remedy against coronavirus. Available from:https:\/\/www.science.org\/content\/article\/new-york-clinical-trial-quietly-tests-heartburn-remedy-against-coronavirus. 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