{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:58:47Z","timestamp":1768265927725,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","award":["BASJ20210413009"],"award-info":[{"award-number":["BASJ20210413009"]}],"id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>As the exact prevalence of portopulmonary hypertension (PoPH) and the etiology of chronic liver disease (CLD) remain unknown, the present study aimed to clarify these points in Japanese patients with CLD using symptom\u2010based questionnaire screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with CLD were asked to complete an eight\u2010item written questionnaire on pulmonary hypertension (PH) symptoms. If at least one item response was \u201cyes,\u201d the patient was offered ultrasonic echocardiography (UCG). Patients identified as having an intermediate or high risk of PH by UCG were referred to a cardiologist for further evaluation, whereby a definitive diagnosis of PoPH was made using right heart catheterization (RHC) findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1111 patients with CLD completed the survey. Of the 566 symptomatic patients with at least one question answered as \u201cyes,\u201d approximately half agreed to undergo UCG (<jats:italic>n<\/jats:italic>\u2009=\u2009267). Compared with asymptomatic patients, symptomatic patients were significantly older, predominantly female, and more frequently exhibited cirrhosis. Based on UCG findings, 228, 12, and 8 patients had a low, intermediate, or high risk for PH, respectively. Intermediate\u2010\/high\u2010risk patients showed significantly more advanced disease progression status than low\u2010risk patients. The frequencies of answer to the eight questions were comparable. Ultimately, three patients were diagnosed as having PoPH (1.1% of UCG cases), one with underlying hepatitis C virus (HCV) infection and two with primary biliary cholangitis (PBC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This symptom\u2010based PoPH screening study clarified the prevalence of PoPH in CLD patients according to a PH symptom questionnaire, UCG, and RHC. Patients with HCV and PBC may have a higher risk of PoPH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12939","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T04:59:41Z","timestamp":1690347581000},"page":"527-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Symptom\u2010based portopulmonary hypertension screening questionnaire in Japanese patients with chronic liver disease"],"prefix":"10.1002","volume":"7","author":[{"given":"Shun\u2010Ichi","family":"Wakabayashi","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6364-9654","authenticated-orcid":false,"given":"Satoru","family":"Joshita","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Department of Health Promotion Medicine Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohiko","family":"Motoki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiki","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Department of Health Promotion Medicine Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0162-4208","authenticated-orcid":false,"given":"Yuki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Department of Advanced Endoscopic Therapy Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoo","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takefumi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Consultation Center for Liver Diseases Shinshu University Hospital  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeji","family":"Umemura","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Department of Health Promotion Medicine Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Department of Advanced Endoscopic Therapy Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Consultation Center for Liver Diseases Shinshu University Hospital  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90225-A"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1606251"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0160"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13560"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200809-1472OC"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80123-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91122-K"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70296-3"},{"key":"e_1_2_7_11_1","first-page":"849","article-title":"Pulmonary hypertension complicating portal hypertension","volume":"120","author":"Lebrec D","year":"1979","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.12.014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22275"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80121-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249435"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01032-2015"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-66-0158"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12269"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13503"},{"key":"e_1_2_7_20_1","first-page":"1509","article-title":"The history of the diagnostic criteria for alcoholic liver disease and current status of alcoholic liver disease in Japan","volume":"109","author":"Tsutsumi M","year":"2012","journal-title":"Nippon Shokakibyo Gakkai Zasshi"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-015-1050-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12270"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1286-x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12300"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1668OC"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.898122"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.09.051"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.5.1313"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13735"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13714"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.011"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12820"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl16365"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000440707"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.02.021"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:24:06Z","timestamp":1693297446000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,25]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/jgh3.12939"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12939","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,25]]},"assertion":[{"value":"2023-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}