{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:22:21Z","timestamp":1747149741151,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Little are known about differences in eosinophilic esophagitis (EoE) patients in the general population compared with patients treated at academic hospitals. This might affect the generalizability of study results. The aims of the study were to compare clinical features, and complications of EoE between patients from a population\u2010based cohort (DanEoE) and patients from an academic hospital cohort in Copenhagen (EoE\u2010Cph).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The DanEoE cohort is a population\u2010 and register\u2010based cohort including all 236 adult EoE patients diagnosed in the North Denmark Region in 2007\u20132017 previously described in detail. The new EoE\u2010Cph cohort consists of 245 consecutively referred adult patients to a dedicated EoE center in an Academic Hospital in the Danish capital in 2013\u20132020. Data were collected from medical registries and medical files.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in the academic cohort were at symptom debut 12 (SD 16) years younger (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). At the time of diagnosis they were 5.4 (SD 15) years younger (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Where Gastro\u2010esophageal reflux disease (GORD) was present in one\u2010third of the population\u2010based cohort, this was only observed in 14% of the EoE\u2010Cph group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Food bolus obstruction before diagnosis was 24% less common in the EoE\u2010Cph patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results indicated that EoE patients referred to a Danish EoE center is a selected subgroup with disease debut at a younger age, less comorbid GORD, and rarely food bolus obstruction before diagnosis. This suggests that study results from academic hospitals might not have generalizability to the average EoE patient in a population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12952","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T07:57:27Z","timestamp":1692431847000},"page":"572-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Are patients with eosinophilic esophagitis treated at an academic hospital comparable to a patient from a population\u2010based cohort? Not in Denmark"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5656-402X","authenticated-orcid":false,"given":"Dorte","family":"Melgaard","sequence":"first","affiliation":[{"name":"MechSense, Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Faculty of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger B","family":"Andersen","sequence":"additional","affiliation":[{"name":"Gastro Unit, Medical Division Hvidovre University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Line T","family":"Frandsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Gastro Unit, Medical Division Hvidovre University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-6944","authenticated-orcid":false,"given":"Line E M","family":"Hansen","sequence":"additional","affiliation":[{"name":"MechSense, Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2228-7132","authenticated-orcid":false,"given":"Anne L","family":"Krarup","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Emergency Medicine and Trauma Center Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dox128"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200504000-00002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12092"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5462.2398"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.301.5630.163"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1206-0852"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-022-03258-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12146"},{"key":"e_1_2_6_11_1","article-title":"No gender differences in patients with eosinophilic oesophagitis","volume":"70","author":"Kozon I","year":"2023","journal-title":"Dan. Med. J."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640616689525"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60487-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8698230"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S9908"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12273"},{"key":"e_1_2_6_17_1","first-page":"1","article-title":"Loss to follow\u2010up after food impaction among patients with and without eosinophilic esophagitis","volume":"32","author":"Chang JW","year":"2020","journal-title":"Dis. 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